[HTML][HTML] On the therapeutic targets and pharmacological treatments for pain relief following spinal cord injury: A mechanistic review

S Fakhri, F Abbaszadeh, M Jorjani - Biomedicine & Pharmacotherapy, 2021 - Elsevier
Spinal cord injury (SCI) is globally considered as one of the most debilitating disorders,
which interferes with daily activities and life of the affected patients. Despite many …

Changes in the biochemical taste of cytoplasmic and cell-free DNA are major fuels for inflamm-aging

G Storci, S De Carolis, F Olivieri, M Bonafè - Seminars in Immunology, 2018 - Elsevier
Inflamm-aging depicts the progressive activation of the innate immune system that
accompanies human aging. Its role as a disease-predisposing condition has been …

Hepatitis B virus impairs TLR9 expression and function in plasmacytoid dendritic cells

IE Vincent, C Zannetti, J Lucifora, H Norder, U Protzer… - PloS one, 2011 - journals.plos.org
Plasmacytoid dendritic cells (pDCs) play a key role in detecting pathogens by producing
large amounts of type I interferon (IFN) by sensing the presence of viral infections through …

Suppressive oligodeoxynucleotides delay the onset of glomerulonephritis and prolong survival in lupus‐prone NZB× NZW mice

L Dong, S Ito, KJ Ishii… - Arthritis & Rheumatism …, 2005 - Wiley Online Library
Objective Synthetic oligodeoxynucleotides (ODN) expressing TTAGGG motifs suppress the
production of proinflammatory cytokines and have been proven effective at blocking the …

TLR9 and the recognition of self and non‐self nucleic acids

MS Lamphier, CM Sirois, A Verma… - Annals of the New …, 2006 - Wiley Online Library
Toll‐like receptors (TLRs) are involved in the innate recognition of foreign material and their
activation leads to both innate and adaptive immune responses directed against invading …

Generation of antigen-specific Foxp3+ regulatory T-cells in vivo following administration of diabetes-reversing tolerogenic microspheres does not require provision of …

C Engman, Y Wen, WS Meng, R Bottino, M Trucco… - Clinical …, 2015 - Elsevier
We have developed novel antisense oligonucleotide-formulated microspheres that can
reverse hyperglycemia in newly-onset diabetic mice. Dendritic cells taking up the …

Enhancement of HIV DNA vaccine immunogenicity by the NKT cell ligand, α-galactosylceramide

Y Huang, A Chen, X Li, Z Chen, W Zhang, Y Song… - Vaccine, 2008 - Elsevier
A number of studies have shown that the natural killer T cell (NKT) ligand α-
galactosylceramide (α-GalCer) serves as an adjuvant for various vaccines, including viral …

Targeting Toll-like receptor signaling in plasmacytoid dendritic cells and autoreactive B cells as a therapy for lupus

PS Lenert - Arthritis research & therapy, 2006 - Springer
This review focuses on the role of Toll-like receptors (TLRs) in lupus and on possibilities to
treat lupus using TLR modulating inhibitory oligodeoxynucleotides (INH-ODNs). TLRs …

A toll-like receptor 9 antagonist reduces pain hypersensitivity and the inflammatory response in spinal cord injury

BT David, A Ratnayake, MA Amarante, NP Reddy… - Neurobiology of …, 2013 - Elsevier
Toll-like receptors (TLRs) are mediators of the innate immune response to exogenous
pathogens. They have also been implicated in sterile inflammation associated with systemic …

Characterization of suppressive oligodeoxynucleotides that inhibit Toll‐like receptor‐9‐mediated activation of innate immunity

M Peter, K Bode, GB Lipford, F Eberle, K Heeg… - …, 2008 - Wiley Online Library
Synthetic oligodeoxynucleotides containing unmethylated CpG sequences (CpG‐ODNs)
stimulate Toll‐like receptor‐9 (TLR‐9), thereby activating innate immunity. Stimulatory CpG …