Fibrosis is defined as an excessive deposition of connective tissue components and can
affect virtually every organ system, including the skin, lungs, liver and kidney. Fibrotic tissue …

Fibrotic diseases are characterized by net accumulation of extracellular matrix proteins in
affected organs leading to their dysfunction and ultimate failure. Myofibroblasts have been …

Background Interstitial lung disease (ILD) is a common manifestation of systemic sclerosis
and a leading cause of systemic sclerosis–related death. Nintedanib, a tyrosine kinase …

Chronic organ injury leads to fibrosis and eventually organ failure. Fibrosis is characterized
by excessive synthesis, remodeling, and contraction of extracellular matrix produced by …

Tissue fibrosis is a pathological condition that is associated with impaired epithelial repair
and excessive deposition of extracellular matrix (ECM). Fibrotic lesions increase the risk of …

Systemic sclerosis (SSc) is a complex disease characterized by early microvascular
abnormalities, immune dysregulation and chronic inflammation, and subsequent fibrosis of …

Transforming growth factor-β (TGF-β) is widely recognized as a core pathway of fibrosis.
Inhibition of TGF-β signaling may thus offer potential for antifibrotic therapies. Long-term …

Fibrotic diseases encompass a wide spectrum of clinical entities including systemic fibrotic
diseases such as systemic sclerosis, sclerodermatous graft versus host disease …

Interstitial lung disease (ILD) encompasses a large and diverse group of pathological
conditions that share similar clinical, radiological and pathological manifestations, despite …

Fibrosis in multiple organs is a prominent pathological finding and distinguishing hallmark of
systemic sclerosis (SSc). Findings during the past 5 years have contributed to a more …