Old World Vipers—a review about snake venom proteomics of Viperinae and their variations

M Damm, BF Hempel, RD Süssmuth - Toxins, 2021 - mdpi.com
Fine-tuned by millions of years of evolution, snake venoms have frightened but also
fascinated humanity and nowadays they constitute potential resources for drug …

Snake venomics: fundamentals, recent updates, and a look to the next decade

CH Tan - Toxins, 2022 - mdpi.com
Venomic research, powered by techniques adapted from proteomics, transcriptomics, and
genomics, seeks to unravel the diversity and complexity of venom through which knowledge …

Small molecule drug discovery for neglected tropical snakebite

RH Clare, SR Hall, RN Patel, NR Casewell - Trends in pharmacological …, 2021 - cell.com
Snakebite envenoming is responsible for as many as 138 000 deaths annually, making it the
world's most lethal neglected tropical disease (NTD). There is an urgent need to improve …

[HTML][HTML] Mutual enlightenment: A toolbox of concepts and methods for integrating evolutionary and clinical toxinology via snake venomics and the contextual stance

JJ Calvete, B Lomonte, AJ Saviola, F Bonilla, M Sasa… - Toxicon: X, 2021 - Elsevier
Snakebite envenoming is a neglected tropical disease that may claim over 100,000 human
lives annually worldwide. Snakebite occurs as the result of an interaction between a human …

Proteomic analysis reveals geographic variation in venom composition of Russell's Viper in the Indian subcontinent: Implications for clinical manifestations post …

B Kalita, SP Mackessy… - Expert review of proteomics, 2018 - Taylor & Francis
ABSTRACT Introduction: The Russell's Viper (RV)(Daboia russelii), a category I medically
important snake, is responsible for a significant level of morbidity and mortality in the Indian …

Quantitative proteomics of Naja annulifera (sub-Saharan snouted cobra) venom and neutralization activities of two antivenoms in Africa

KY Tan, KY Wong, NH Tan, CH Tan - International journal of biological …, 2020 - Elsevier
Envenomation by Naja annulifera (snouted cobra), a non-spitting African cobra, can result in
local tissue damage and fatal paralysis but a species-specific antivenom treatment is …

A neurotoxic snake venom without phospholipase A2: Proteomics and cross-neutralization of the venom from Senegalese cobra, Naja senegalensis (Subgenus …

KY Wong, KY Tan, NH Tan, CH Tan - Toxins, 2021 - mdpi.com
The Senegalese cobra, Naja senegalensis, is a non-spitting cobra species newly erected
from the Naja haje complex. Naja senegalensis causes neurotoxic envenomation in …

In Vitro Efficacy of Antivenom and Varespladib in Neutralising Chinese Russell's Viper (Daboia siamensis) Venom Toxicity

M Lay, Q Liang, GK Isbister, WC Hodgson - Toxins, 2023 - mdpi.com
The venom of the Russell's viper (Daboia siamensis) contains neurotoxic and myotoxic
phospholipase A2 toxins which can cause irreversible damage to motor nerve terminals …

Quantitative proteomic analysis of venom from Southern India common krait (Bungarus caeruleus) and identification of poorly immunogenic toxins by immune …

A Patra, A Chanda, AK Mukherjee - Expert review of proteomics, 2019 - Taylor & Francis
Objectives: To study the venom proteome composition of Southern India (SI) Common Krait
(Bungarus caeruleus) and immunological cross-reactivity between venom against …

Varespladib (LY315920) rescued mice from fatal neurotoxicity caused by venoms of five major Asiatic kraits (Bungarus spp.) in an experimental envenoming and …

CH Tan, TMC Lingam, KY Tan - Acta Tropica, 2022 - Elsevier
The venoms of Asiatic kraits (Bungarus spp.) contain various neurotoxic phospholipases A 2
(beta-bungarotoxins) which can irreversibly damage motor nerve terminals, resulting in …