Caenorhabditis elegans RAC1/ced-10 mutants as a new animal model to study very early stages of Parkinson's disease
Patients with Parkinson's disease (PD) display non-motor symptoms arising prior to the
appearance of motor signs and before a clear diagnosis. Motor and non-motor symptoms …
appearance of motor signs and before a clear diagnosis. Motor and non-motor symptoms …
Integrated regulation of dopaminergic and epigenetic effectors of neuroprotection in Parkinson's disease models
JB Nourse Jr, SN Russell, NA Moniz… - Proceedings of the …, 2023 - National Acad Sciences
Whole-exome sequencing of Parkinson's disease (PD) patient DNA identified single-
nucleotide polymorphisms (SNPs) in the tyrosine nonreceptor kinase-2 (TNK2) gene …
nucleotide polymorphisms (SNPs) in the tyrosine nonreceptor kinase-2 (TNK2) gene …
Variant functional assessment in Drosophila by overexpression: what can we learn?
Y Her, DM Pascual, Z Goldstone-Joubert… - …, 2024 - cdnsciencepub.com
The last decade has been highlighted by the increased use of next-generation DNA
sequencing technology to identify novel human disease genes. A critical downstream part of …
sequencing technology to identify novel human disease genes. A critical downstream part of …
Xanthine Dehydrogenase Is a Modulator of Dopaminergic Neurodegeneration in Response to Bacterial Metabolite Exposure in C. elegans
JL Thies, K Willicott, ML Craig, MR Greene, CN DuGay… - Cells, 2023 - mdpi.com
Oxidative stress is a contributing factor to Parkinson's disease (PD). Considering the
prevalence of sporadic PD, environmental exposures are postulated to increase reactive …
prevalence of sporadic PD, environmental exposures are postulated to increase reactive …
Mechanistic impacts of bacterial diet on dopaminergic neurodegeneration in a Caenorhabditis elegans α-synuclein model of Parkinson's disease
AL Gaeta, K Willicott, CW Willicott, LE McKay… - iScience, 2023 - cell.com
Failure of inherently protective cellular processes and misfolded protein-associated stress
contribute to the progressive loss of dopamine (DA) neurons characteristic of Parkinson's …
contribute to the progressive loss of dopamine (DA) neurons characteristic of Parkinson's …
Dietary Curcumin Intake and Its Effects on the Transcriptome and Metabolome of Drosophila melanogaster
S Belcher, G Flores-Iga, P Natarajan… - International Journal of …, 2024 - mdpi.com
Curcumin, a polyphenol derived from Curcuma longa, used as a dietary spice, has garnered
attention for its therapeutic potential, including antioxidant, anti-inflammatory, and …
attention for its therapeutic potential, including antioxidant, anti-inflammatory, and …
Back to the future through the wormhole: Caenorhabditis elegans as a preclinical model
GA Caldwell - Disease Models & Mechanisms, 2023 - journals.biologists.com
On the 15th Anniversary of Disease Models & Mechanisms as a trailblazing venue for the
dissemination of discoveries pertaining to human health involving model systems, we …
dissemination of discoveries pertaining to human health involving model systems, we …
Human Molecular Genetics Review Issue 2022
F Cheng, D Geschwind - Human Molecular Genetics, 2022 - academic.oup.com
Recent remarkable advances in high-throughput genotyping and next-generation DNA-
sequencing technologies have generated massive human genome sequencing datasets …
sequencing technologies have generated massive human genome sequencing datasets …
Attenuation of Dopaminergic Neurodegeneration in a C. elegans Parkinson's Model through Regulation of Xanthine Dehydrogenase (XDH-1) Expression by the RNA …
LA Starr, LE McKay, KN Peter, LM Seyfarth… - Journal of …, 2023 - mdpi.com
Differential RNA editing by adenosine deaminases that act on RNA (ADARs) has been
implicated in several neurological disorders, including Parkinson's disease (PD). Here, we …
implicated in several neurological disorders, including Parkinson's disease (PD). Here, we …
Analysis of Date Fruit Genetic Variety Based on Feature Selection and Classification Using Deep Learning Architectures
A Alshammari - 2022 IEEE 8th International Conference on …, 2022 - ieeexplore.ieee.org
Deep learning has made significant strides recently, making it a popular option for image
processing applications. However, because to similarities in color, shape, and size of fruits …
processing applications. However, because to similarities in color, shape, and size of fruits …