Cancer stem cells (CSCs) are a highly tumorigenic subpopulation of the cancer cells within
a tumor that drive tumor initiation, progression, and therapy resistance. In general, stem cell …

The extraembryonic yolk sac (YS) ensures delivery of nutritional support and oxygen to the
developing embryo but remains ill-defined in humans. We therefore assembled a …

Simple Summary B-cell acute lymphoblastic leukemia (B-ALL) is the most common pediatric
cancer. Even though the cure rate actually exceeds 85%, the prognosis of …

The drugs used for treating bone diseases (BDs), at present, elicit hazardous side effects
that include certain types of cancers and strokes, hence the ongoing quest for the discovery …

The central nervous system (CNS) influences the immune system generally by regulating
the systemic concentration of humoral substances (eg, cortisol and epinephrine), whereas …

T cells develop from multipotent progenitors by a gradual process dependent on intrathymic
Notch signaling and coupled with extensive proliferation. The stages leading them to T-cell …

Conditioning of the bone marrow prior to haematopoietic stem cell transplant is essential in
eradicating the primary cause of disease, facilitating donor cell engraftment and avoiding …

Nowadays, new advances in society and health have brought an increased life expectancy.
However, at the same time, aging comes with complications that impact the development of …

The process of aging and escalating the failure of all body organs has become the center of
interest in contemporary science and medicine. The leading role of phosphate-calcium …

Multiple myeloma (MM) is a dyscrasia of plasma cells (PCs) characterized by abnormal
immunoglobulin (Ig) production. The disease remains incurable due to a multitude of …