Early identification, accurate diagnosis, and treatment of silicosis

T Li, X Yang, H Xu, H Liu - Canadian respiratory journal, 2022 - Wiley Online Library
Silicosis is a global problem, and it has brought about great burdens to society and patients'
families. The etiology of silicosis is clear, preventable, and controllable, but the onset is …

The role of trace elements and minerals in osteoporosis: a review of epidemiological and laboratory findings

AV Skalny, M Aschner, EV Silina, VA Stupin… - Biomolecules, 2023 - mdpi.com
The objective of the present study was to review recent epidemiological and clinical data on
the association between selected minerals and trace elements and osteoporosis, as well as …

Glycolytic reprogramming in silica-induced lung macrophages and silicosis reversed by Ac-SDKP treatment

N Mao, H Yang, J Yin, Y Li, F Jin, T Li, X Yang… - International Journal of …, 2021 - mdpi.com
Glycolytic reprogramming is an important metabolic feature in the development of pulmonary
fibrosis. However, the specific mechanism of glycolysis in silicosis is still not clear. In this …

Thalidomide alleviates pulmonary fibrosis induced by silica in mice by inhibiting ER stress and the TLR4-NF-κB pathway

Y Li, W Cai, F Jin, X Wang, W Liu, T Li, X Yang… - International Journal of …, 2022 - mdpi.com
Silicosis is the most prevalent occupational disease in China. It is a form of pulmonary
fibrosis caused by the inhalation of silicon particles. As there is no cure for the potentially …

Ac-SDKP attenuates activation of lung macrophages and bone osteoclasts in rats exposed to silica by inhibition of TLR4 and RANKL signaling pathways

F Jin, F Geng, D Xu, Y Li, T Li, X Yang… - Journal of …, 2021 - Taylor & Francis
Background: Silica-induced inflammatory activation is associated with silicosis and various
non-respiratory conditions. The present study was designed to examine the anti …

Transcriptomic analysis identifies upregulation of secreted phosphoprotein 1 in silicotic rats

W Cai, B Zhang, T Li, F Jin, Y Li… - Experimental and …, 2021 - spandidos-publications.com
Silicosis is caused by exposure to crystalline silica and the molecular mechanism of silicotic
fibrosis remains unclear. Therefore, the present study investigated the mRNA profiles of rats …

MiR-411–3p alleviates Silica-induced pulmonary fibrosis by regulating Smurf2/TGF-β signaling

X Gao, H Xu, D Xu, S Li, Z Wei, S Li, W Cai… - Experimental Cell …, 2020 - Elsevier
Occupational exposure to silica dust particles was the major cause of pulmonary fibrosis,
and many miRNAs have been demonstrated to regulate target mRNAs in silicosis. In the …

OC‐STAMP Overexpression Drives Lung Alveolar Epithelial Cell Type II Senescence in Silicosis

T Li, X Yang, D Xu, Z Gao, Y Gao, F Jin… - Oxidative Medicine …, 2021 - Wiley Online Library
Cellular senescence has been considered an important driver of many chronic lung
diseases. However, the specific mechanism of cellular senescence in silicosis is still …

Minute cellular nodules as early lesions in rats with silica exposure via inhalation

Y Li, F Jin, T Li, X Yang, W Cai, S Li, X Gao, N Mao… - Veterinary …, 2022 - mdpi.com
Mechanisms of silicosis have yet to be clarified, and pathological conditions are inaccurately
described in some experimental studies on silicosis. This study was aimed at describing …

Role of RANKL in alveolar epithelial cell regeneration: potential novel contributor to lung tissue repair

H Habibie, S Song, CE Boorsma, KSS Putri… - bioRxiv, 2023 - biorxiv.org
Receptor activator for NF-kappa beta (RANK) ligand (RANKL) is found in lung tissue and
elevated in lung diseases like chronic obstructive pulmonary disease (COPD), cystic fibrosis …