Reactive oxygen species, toxicity, oxidative stress, and antioxidants: Chronic diseases and aging

K Jomova, R Raptova, SY Alomar, SH Alwasel… - Archives of …, 2023 - Springer
A physiological level of oxygen/nitrogen free radicals and non-radical reactive species
(collectively known as ROS/RNS) is termed oxidative eustress or “good stress” and is …

A review of machine learning and deep learning approaches on mental health diagnosis

NK Iyortsuun, SH Kim, M Jhon, HJ Yang, S Pant - Healthcare, 2023 - mdpi.com
Combating mental illnesses such as depression and anxiety has become a global concern.
As a result of the necessity for finding effective ways to battle these problems, machine …

The role of gut dysbiosis in the pathophysiology of neuropsychiatric disorders

N Anand, VR Gorantla, SB Chidambaram - Cells, 2022 - mdpi.com
Mounting evidence shows that the complex gut microbial ecosystem in the human
gastrointestinal (GI) tract regulates the physiology of the central nervous system (CNS) via …

Muscarinic acetylcholine receptor agonists as novel treatments for schizophrenia

SM Paul, SE Yohn, M Popiolek… - American Journal of …, 2022 - Am Psychiatric Assoc
Schizophrenia remains a challenging disease to treat effectively with current antipsychotic
medications due to their limited efficacy across the entire spectrum of core symptoms as well …

Neuroinflammation in schizophrenia: the key role of the WNT/β-catenin pathway

A Vallée - International Journal of Molecular Sciences, 2022 - mdpi.com
Schizophrenia is a very complex syndrome involving widespread brain multi-
dysconnectivity. Schizophrenia is marked by cognitive, behavioral, and emotional …

[HTML][HTML] The dual hit hypothesis of schizophrenia: Evidence from animal models

CGJ Guerrin, J Doorduin, IE Sommer… - … & Biobehavioral Reviews, 2021 - Elsevier
Schizophrenia is a heterogeneous psychiatric disorder, which can severely impact social
and professional functioning. Epidemiological and clinical studies show that schizophrenia …

New and emerging treatments for schizophrenia: a narrative review of their pharmacology, efficacy and side effect profile relative to established antipsychotics

MC Lobo, TS Whitehurst, SJ Kaar, OD Howes - … & Biobehavioral Reviews, 2022 - Elsevier
Schizophrenia is associated with substantial unmet needs, highlighting the necessity for
new treatments. This narrative review compares the pharmacology, clinical trial data and …

High-throughput screening platforms in the discovery of novel drugs for neurodegenerative diseases

H Aldewachi, RN Al-Zidan, MT Conner, MM Salman - Bioengineering, 2021 - mdpi.com
Neurodegenerative diseases (NDDs) are incurable and debilitating conditions that result in
progressive degeneration and/or death of nerve cells in the central nervous system (CNS) …

[HTML][HTML] Glycosylation and behavioral symptoms in neurological disorders

P Pradeep, H Kang, B Lee - Translational Psychiatry, 2023 - nature.com
Glycosylation, the addition of glycans or carbohydrates to proteins, lipids, or other glycans, is
a complex post-translational modification that plays a crucial role in cellular function. It is …

Genome-wide Mendelian randomization identifies actionable novel drug targets for psychiatric disorders

J Liu, Y Cheng, M Li, Z Zhang, T Li… - …, 2023 - nature.com
Psychiatric disorders impose tremendous economic burden on society and are leading
causes of disability worldwide. However, only limited drugs are available for psychiatric …