Inflammasomes are large protein complexes that play a major role in sensing inflammatory
signals and triggering the innate immune response. Each inflammasome complex has three …

Acute kidney injury (AKI) frequently occurs in patients with chronic kidney disease (CKD)
and in turn, may cause or accelerate CKD. Therapeutic options in AKI are limited and mostly …

Complement is dysregulated in the brain in Alzheimer's Disease and in mouse models of
Alzheimer's disease. Each of the complement derived effectors, opsonins, anaphylatoxins …

Noncoding RNAs (ncRNAs) are a class of nucleotide sequences that cannot be translated
into peptides. ncRNAs can function post-transcriptionally by splicing complementary …

Abstract Treatment of glaucoma, the leading cause of irreversible blindness, remains
challenging. The apoptotic loss of retinal ganglion cells (RGCs) in glaucoma is the …

Research evidence indicating common metabolic mechanisms through which type 2
diabetes mellitus (T2DM) increases risk of late-onset Alzheimer's dementia (LOAD) has …

NLRP3 inflammasome activation has emerged as a critical initiator of inflammatory response
in ischemic retinopathy. Here, we identified the effect of a potent, selective NLRP3 inhibitor …

Alzheimer's disease is characterized by deposition of amyloid-β protein (Aβ), which forms
extracellular neuritic plaques, and accumulation of hyperphosphorylated tau, which …

Background: This study was to investigate the relationship between chronic constipation,
diarrhea, and depression among the elderly, as the extent of their association remains …