Breast cancer is the most commonly diagnosed cancer in the USA. Although advances in
treatment over the past several decades have significantly improved the outlook for this …

Among mouse mammary tumor models, syngeneic cell lines present an advantage for the
study of immune response. However, few of these models are well characterized. The tumor …

Patients with advanced stage cancers frequently suffer from severe pain as a result of bone
metastasis and bone destruction, for which there is no efficacious treatment. Here, using …

Background Despite decades of therapeutic trials, effective diagnosis, many drugs available
and numerous studies on breast cancer, it remains the deadliest cancer in women. In order …

Abstract Insulin growth factor-1 (IGF-1), an osteoclast-dependent osteolysis biomarker,
contributes to metastatic bone cancer pain (MBCP), but the underlying mechanism is poorly …

The secreted protein sclerostin is primarily produced by osteocytes and suppresses
osteoblast differentiation and function by inhibiting the canonical Wnt signaling pathway …

The complex interplay between malignant cells and the cellular and molecular components
of the tumor stroma is a key aspect of cancer growth and development. These tumor–host …

Decorin, a small leucine-rich proteoglycan with multiple biological functions, is known to
evoke autophagy and mitophagy in both endothelial and cancer cells. Here, we investigated …

MicroRNAs (miRNAs) are small non-coding RNAs that can post-transcriptionally regulate
the genes involved in critical cellular processes. The aberrant expressions of oncogenic or …

The immune system plays a crucial role in cancer development and progression. More than
a century ago, mouse models showed that primary tumors suppressed the growth of newly …