Interactions of glial cells with neuronal synapses, from astrocytes to microglia and oligodendrocyte lineage cells
The mammalian brain is a complex organ comprising neurons, glia, and more than 1× 1014
synapses. Neurons are a heterogeneous group of electrically active cells, which form the …
synapses. Neurons are a heterogeneous group of electrically active cells, which form the …
The glymphatic system: a new perspective on brain diseases
Z Ding, X Fan, Y Zhang, M Yao, G Wang… - Frontiers in Aging …, 2023 - frontiersin.org
The glymphatic system is a brain-wide perivascular pathway driven by aquaporin-4 on the
endfeet of astrocytes, which can deliver nutrients and active substances to the brain …
endfeet of astrocytes, which can deliver nutrients and active substances to the brain …
Inflammation in pathogenesis of chronic pain: Foe and friend
XX Fang, MN Zhai, M Zhu, C He, H Wang… - Molecular …, 2023 - journals.sagepub.com
Chronic pain is a refractory health disease worldwide causing an enormous economic
burden on individuals and society. Accumulating evidence suggests that inflammation in the …
burden on individuals and society. Accumulating evidence suggests that inflammation in the …
The role of neuroinflammation in complex regional pain syndrome: a comprehensive review
Abstract Complex Regional Pain Syndrome (CRPS) is an excess and/or prolonged pain and
inflammation condition that follows an injury to a limb. The pathogenesis of CRPS is …
inflammation condition that follows an injury to a limb. The pathogenesis of CRPS is …
Emodin alleviates chronic constriction injury-induced neuropathic pain and inflammation via modulating PPAR-gamma pathway
Neuropathic pain has been characterized as chronic pain resulting from pathological
damage to the sensorimotor system. Because of its complex nature, it remains refractory to …
damage to the sensorimotor system. Because of its complex nature, it remains refractory to …
Ion channels in cancer-induced bone pain: from molecular mechanisms to clinical applications
HJ Lu, XB Wu, QQ Wei - Frontiers in Molecular Neuroscience, 2023 - frontiersin.org
Cancer-induced bone pain (CIBP) caused by bone metastasis is one of the most prevalent
diseases, and current treatments rely primarily on opioids, which have significant side …
diseases, and current treatments rely primarily on opioids, which have significant side …
Turmeric Bioactive Compounds Alleviate Spinal Nerve Ligation-Induced Neuropathic Pain by Suppressing Glial Activation and Improving Mitochondrial Function in …
This study examined the effects of turmeric bioactive compounds, curcumin C3
complex®(CUR) and bisdemethoxycurcumin (BDMC), on mechanical hypersensitivity and …
complex®(CUR) and bisdemethoxycurcumin (BDMC), on mechanical hypersensitivity and …
Modulation of visceral pain by brain nuclei and brain circuits and the role of acupuncture: a narrative review
Z Dou, N Su, Z Zhou, A Mi, L Xu, J Zhou… - Frontiers in …, 2023 - frontiersin.org
Visceral pain is a complex and heterogeneous pain condition that is often associated with
pain-related negative emotional states, including anxiety and depression, and can exert …
pain-related negative emotional states, including anxiety and depression, and can exert …
Astrocyte PERK and IRE1 Signaling Contributes to Morphine Tolerance and Hyperalgesia through Upregulation of Lipocalin-2 and NLRP3 Inflammasome in the …
B Wang, LN Wang, B Wu, R Guo, L Zhang… - …, 2024 - pubs.asahq.org
Background Endoplasmic reticulum stress plays a crucial role in the pathogenesis of
neuroinflammation and chronic pain. This study hypothesized that PRKR-like endoplasmic …
neuroinflammation and chronic pain. This study hypothesized that PRKR-like endoplasmic …
[HTML][HTML] The role of N6-methyladenosine modification in rodent models of neuropathic pain: from the mechanism to therapeutic potential
L Wu, H Tang - Biomedicine & Pharmacotherapy, 2023 - Elsevier
Neuropathic pain (NP) is a common chronic pain condition resulted from lesions or diseases
of somatosensory nervous system, but the pathogenesis remains unclear. A growing body of …
of somatosensory nervous system, but the pathogenesis remains unclear. A growing body of …