[HTML][HTML] Multiplexed profiling of extracellular vesicles for biomarker development

C Jiang, Y Fu, G Liu, B Shu, J Davis, GK Tofaris - Nano-micro letters, 2022 - Springer
Extracellular vesicles (EVs) are cell-derived membranous particles that play a crucial role in
molecular trafficking, intercellular transport and the egress of unwanted proteins. They have …

A guide to mass spectrometric analysis of extracellular vesicle proteins for biomarker discovery

I Jalaludin, DM Lubman, J Kim - Mass Spectrometry Reviews, 2023 - Wiley Online Library
Exosomes (small extracellular vesicles) in living organisms play an important role in
processes such as cell proliferation or intercellular communication. Recently, exosomes …

exoRBase 2.0: an atlas of mRNA, lncRNA and circRNA in extracellular vesicles from human biofluids

H Lai, Y Li, H Zhang, J Hu, J Liao, Y Su… - Nucleic acids …, 2022 - academic.oup.com
Extracellular vesicles (EVs) are small membranous vesicles that contain an abundant cargo
of different RNA species with specialized functions and clinical implications. Here, we …

[HTML][HTML] Diagnostic value of liquid biopsy in the era of precision medicine: 10 years of clinical evidence in cancer

V Caputo, F Ciardiello, CM Della Corte… - … of targeted anti-tumor …, 2023 - ncbi.nlm.nih.gov
Liquid biopsy is a diagnostic repeatable test, which in last years has emerged as a powerful
tool for profiling cancer genomes in real-time with minimal invasiveness and tailoring …

EV‐ADD, a database for EV‐associated DNA in human liquid biopsy samples

T Tsering, M Li, Y Chen, A Nadeau… - Journal of …, 2022 - Wiley Online Library
Extracellular vesicles (EVs) play a key role in cellular communication both in physiological
conditions and in pathologies such as cancer. Emerging evidence has shown that EVs are …

Status quo of Extracellular Vesicle isolation and detection methods for clinical utility

KS Visan, LY Wu, S Voss, A Wuethrich… - Seminars in Cancer …, 2023 - Elsevier
Extracellular vesicles (EVs) are nano-sized particles that hold tremendous potential in the
clinical space, as their biomolecular profiles hold a key to non-invasive liquid biopsy for …

Carboxypeptidase E and its splice variants: Key regulators of growth and metastasis in multiple cancer types

S Hareendran, X Yang, VK Sharma, YP Loh - Cancer letters, 2022 - Elsevier
Mechanisms driving tumor growth and metastasis are complex, and involve the recruitment
of many genes working in concert with each other. The tumor is characterized by the …

Extracellular vesicle‐bound DNA in urine is indicative of kidney allograft injury

I Sedej, M Štalekar, M Tušek Žnidarič… - Journal of …, 2022 - Wiley Online Library
Extracellular vesicle‐bound DNA (evDNA) is an understudied extracellular vesicle (EV)
cargo, particularly in cancer‐unrelated research. Although evDNA has been detected in …

[HTML][HTML] Mucins as potential biomarkers for early detection of cancer

SK Gautam, P Khan, G Natarajan, P Atri, A Aithal… - Cancers, 2023 - mdpi.com
Simple Summary Early cancer detection is a challenge in treating cancer patients.
Remarkably, carcinomas of the breast, lung, liver, pancreas, ovary, and colon contribute to …

Circulating cancer‐associated extracellular vesicles as early detection and recurrence biomarkers for pancreatic cancer

Y Yoshioka, M Shimomura, K Saito, H Ishii… - Cancer …, 2022 - Wiley Online Library
Early detection of pancreatic ductal adenocarcinoma (PDAC) is essential for improving
patient survival rates, and noninvasive biomarkers are urgently required to identify patients …