Many epidemiological observational studies suggest that a high-fat diet (HFD) accelerates
the risk of colorectal cancer (CRC). Inflammation can play a key role in the relationship …

Insulators are architectural elements implicated in the organization of higher-order
chromatin structures and transcriptional regulation. However, it is still unknown how …

Telomeres in all organisms must perform the same vital functions to ensure cell viability: to
act as a protective chromosome cap that distinguishes natural chromosome ends from DNA …

Telomeres in Drosophila are maintained by the specialized telomeric retrotransposons HeT-
A, TART and TAHRE. Sense transcripts of telomeric retroelements were shown to be the …

The remarkable diversity in the contents of genomes raises questions about how new genes
and new functions originate. Recent evidence indicates that parasitism, particularly the …

Analysis of cells in culture has made substantial contributions to biological research. The
versatility and scale of in vitro manipulation and new applications such as high-throughput …

Telomeres in Drosophila are maintained by transpositions of specialized telomeric
retroelements HeT-A and TART rather than by the telomerase activity adding short DNA …

Media attention and the subsequent scientific backlash engendered by the claim by
spokespeople for the Encyclopedia of DNA Elements (ENCODE) project that 80% of the …

The germline-specific role of telomeres consists of chromosome end elongation and proper
chromosome segregation during early developmental stages. Despite the crucial role of …

In the Drosophila germline, transposable elements (TEs) are silenced by PIWI-interacting
RNA (piRNA) that originate from distinct genomic regions termed piRNA clusters and are …