Maturation is the last phase of heart development that prepares the organ for strong,
efficient, and persistent pumping throughout the mammal's lifespan. This process is …

Defining how organ size is regulated, a process controlled not only by the number of cells
but also by the size of the cells, is a frontier in developmental biology. Large cells are …

Polyploidy is a key mechanism of genome evolution and speciation, particularly in plants.
Many aspects of polyploidy have been elucidated with the tools that have become available …

Diploid and stable karyotypes are associated with health and fitness in animals. By contrast,
whole-genome duplications—doublings of the entire complement of chromosomes—are …

Cancer research has traditionally focused on the characterization of individual molecular
mechanisms that can contribute to cancer. Due to the multiple levels of genomic and non …

Endoreduplication is the major source of somatic endopolyploidy in higher plants, and leads
to variation in cell ploidy levels due to iterative rounds of DNA synthesis in the absence of …

Background Polyploidy provides new genetic material that facilitates evolutionary novelty,
species adaptation, and crop domestication. Polyploidy often leads to an increase in cell or …

Neural stem cells (NSCs) live in an intricate cellular microenvironment supporting their
activity, the niche. Whilst shape and function are inseparable, the morphogenetic aspects of …

Non-centrosomal microtubule-organizing centres (ncMTOCs) have a variety of roles that are
presumed to serve the diverse functions of the range of cell types in which they are found …

Prokaryotic genomes are generally organized in haploid. In synthetic biological research,
efficient chassis cells must be constructed to produce bio‐based products. Here, the …