Extensive evidence has indicated that the breakdown of myelin is associated with
Alzheimer's disease (AD) since the vulnerability of oligodendrocytes under Alzheimer's …

Invasive, site-specific metabolite information could be better obtained from tissues. Hence,
highly sensitive mass spectrometry-based metabolomics coupled with separation …

Alzheimer's disease (AD) is the most common cause of dementia, accounting for an
estimated 60–80% of cases, and is the sixth-leading cause of death in the United States …

AMPK is a key regulator at the molecular level for maintaining energy metabolism
homeostasis. Mammalian AMPK is a heterotrimeric complex, and its catalytic α subunit …

A common symptom in Alzheimer's disease (AD) is cognitive decline, of which the potential
pathogenesis remains unclear. In order to understand the mechanism of gut microbiota in …

Danggui Shaoyao San (DSS), a well-known formula, has been successfully applied in
treating primary dysmenorrhea (PD) in China. However, its material basis and mechanism …

Metabolomics based on direct mass spectrometry (MS) analysis, either by direct infusion or
flow injection of crude sample extracts, shows a great potential for metabolic fingerprinting …

Alzheimer's disease (AD) is the most common neurodegenerative disorder worldwide, but its
etiology is still not completely understood. The identification of underlying pathological …

The identification of pathological mechanisms underlying to Alzheimer's disease is of great
importance for the discovery of potential markers for diagnosis and disease monitoring. In …

Currently, there is no cure for Alzheimer's disease and early diagnosis is very difficult, since
no biomarkers have been established with the necessary reliability and specificity. For the …