Schizophrenia is recognized to be a highly heterogeneous disease at various levels, from
genetics to clinical manifestations and treatment sensitivity. This heterogeneity is also …

Oligodendrocyte precursor cells (OPCs) account for 5% of the resident parenchymal central
nervous system glial cells. OPCs are not only a back-up for the loss of oligodendrocytes that …

Oligodendrocytes are glial cells that populate the entire CNS after they have differentiated
from oligodendrocyte progenitor cells. From birth onward, oligodendrocytes initiate wrapping …

Demyelination in MS disrupts nerve signals and contributes to axon degeneration. While
remyelination promises to restore lost function, it remains unclear whether remyelination will …

Astrocytes are the major glial cell of the central nervous system (CNS), providing both
metabolic and physical support to other neural cells. After injury, astrocytes become reactive …

Multiple sclerosis (MS) is a chronic progressive disabling disease of the central nervous
system (CNS) characterized by demyelination and neuronal injury. Dyslipidemia is observed …

If" the connectome" represents a complete map of anatomical and functional connectivity in
the brain, it should also include glia. Glia define and regulate both the brain's anatomical …

Astrocytes are a diverse and heterogeneous type of glial cells. The major task of grey and
white matter areas in the brain are computation of information at neuronal synapses and …

Neurons and glial cells exchange energy-rich metabolites and it has been suggested,
originally based on in vitro data, that astrocytes provide lactate to glutamatergic synapses …

In several neurodegenerative diseases and myelin disorders, the degeneration profiles of
myelinated axons are compatible with underlying energy deficits. However, it is presently …