Transgenerational epigenetic inheritance: myths and mechanisms
E Heard, RA Martienssen - Cell, 2014 - cell.com
Since the human genome was sequenced, the term" epigenetics" is increasingly being
associated with the hope that we are more than just the sum of our genes. Might what we …
associated with the hope that we are more than just the sum of our genes. Might what we …
Parental olfactory experience influences behavior and neural structure in subsequent generations
BG Dias, KJ Ressler - Nature neuroscience, 2014 - nature.com
Using olfactory molecular specificity, we examined the inheritance of parental traumatic
exposure, a phenomenon that has been frequently observed, but not understood. We …
exposure, a phenomenon that has been frequently observed, but not understood. We …
Systems analysis of sex differences reveals an immunosuppressive role for testosterone in the response to influenza vaccination
Females have generally more robust immune responses than males for reasons that are not
well-understood. Here we used a systems analysis to investigate these differences by …
well-understood. Here we used a systems analysis to investigate these differences by …
Epigenetics and the environment: emerging patterns and implications
R Feil, MF Fraga - Nature reviews genetics, 2012 - nature.com
Epigenetic phenomena in animals and plants are mediated by DNA methylation and stable
chromatin modifications. There has been considerable interest in whether environmental …
chromatin modifications. There has been considerable interest in whether environmental …
Plastics derived endocrine disruptors (BPA, DEHP and DBP) induce epigenetic transgenerational inheritance of obesity, reproductive disease and sperm epimutations
M Manikkam, R Tracey, C Guerrero-Bosagna… - PloS one, 2013 - journals.plos.org
Environmental compounds are known to promote epigenetic transgenerational inheritance
of adult onset disease in subsequent generations (F1–F3) following ancestral exposure …
of adult onset disease in subsequent generations (F1–F3) following ancestral exposure …
Epigenetic mechanisms in diabetic complications and metabolic memory
MA Reddy, E Zhang, R Natarajan - Diabetologia, 2015 - Springer
The incidence of diabetes and its associated micro-and macrovascular complications is
greatly increasing worldwide. The most prevalent vascular complications of both type 1 and …
greatly increasing worldwide. The most prevalent vascular complications of both type 1 and …
Psychological stress in childhood and susceptibility to the chronic diseases of aging: moving toward a model of behavioral and biological mechanisms.
Among people exposed to major psychological stressors in early life, there are elevated
rates of morbidity and mortality from chronic diseases of aging. The most compelling data …
rates of morbidity and mortality from chronic diseases of aging. The most compelling data …
Transgenerational inheritance: how impacts to the epigenetic and genetic information of parents affect offspring health
BACKGROUND A defining feature of sexual reproduction is the transmission of genomic
information from both parents to the offspring. There is now compelling evidence that the …
information from both parents to the offspring. There is now compelling evidence that the …
Epigenetic responses and the developmental origins of health and disease
D Goyal, SW Limesand, R Goyal - Journal of Endocrinology, 2019 - joe.bioscientifica.com
Maternal and paternal factors influence offspring development and program its genome for
successful postnatal life. Based on the stressors during gestation, the pregnant female …
successful postnatal life. Based on the stressors during gestation, the pregnant female …
Paternal stress exposure alters sperm microRNA content and reprograms offspring HPA stress axis regulation
AB Rodgers, CP Morgan, SL Bronson… - Journal of …, 2013 - Soc Neuroscience
Neuropsychiatric disease frequently presents with an underlying hyporeactivity or
hyperreactivity of the HPA stress axis, suggesting an exceptional vulnerability of this circuitry …
hyperreactivity of the HPA stress axis, suggesting an exceptional vulnerability of this circuitry …