[HTML][HTML] Deep whole-genome sequencing reveals recent selection signatures linked to evolution and disease risk of Japanese
Understanding natural selection is crucial to unveiling evolution of modern humans. Here,
we report natural selection signatures in the Japanese population using 2234 high-depth …
we report natural selection signatures in the Japanese population using 2234 high-depth …
[HTML][HTML] Archaic hominin admixture facilitated adaptation to out-of-Africa environments
As modern humans dispersed from Africa throughout the world, they encountered and
interbred with archaic hominins, including Neanderthals and Denisovans [1, 2]. Although …
interbred with archaic hominins, including Neanderthals and Denisovans [1, 2]. Although …
Recovering signals of ghost archaic introgression in African populations
A Durvasula, S Sankararaman - Science Advances, 2020 - science.org
While introgression from Neanderthals and Denisovans has been documented in modern
humans outside Africa, the contribution of archaic hominins to the genetic variation of …
humans outside Africa, the contribution of archaic hominins to the genetic variation of …
[HTML][HTML] Speciation and Introgression between Mimulus nasutus and Mimulus guttatus
Mimulus guttatus and M. nasutus are an evolutionary and ecological model sister species
pair differentiated by ecology, mating system, and partial reproductive isolation. Despite …
pair differentiated by ecology, mating system, and partial reproductive isolation. Despite …
[HTML][HTML] Impacts of Neanderthal-introgressed sequences on the landscape of human gene expression
Regulatory variation influencing gene expression is a key contributor to phenotypic diversity,
both within and between species. Unfortunately, RNA degrades too rapidly to be recovered …
both within and between species. Unfortunately, RNA degrades too rapidly to be recovered …
[HTML][HTML] Identifying and interpreting apparent Neanderthal ancestry in African individuals
Admixture has played a prominent role in shaping patterns of human genomic variation,
including gene flow with now-extinct hominins like Neanderthals and Denisovans. Here, we …
including gene flow with now-extinct hominins like Neanderthals and Denisovans. Here, we …
Haplotype-resolved genome sequencing: experimental methods and applications
MW Snyder, A Adey, JO Kitzman… - Nature Reviews Genetics, 2015 - nature.com
Human genomes are diploid and, for their complete description and interpretation, it is
necessary not only to discover the variation they contain but also to arrange it onto …
necessary not only to discover the variation they contain but also to arrange it onto …
Ancient Ethiopian genome reveals extensive Eurasian admixture throughout the African continent.
M Gallego Llorente, E Jones, A Eriksson, V Siska… - 2015 - repository.cam.ac.uk
Characterizing genetic diversity in Africa is a crucial step for most analyses reconstructing
the evolutionary history of anatomically modern humans. However, historic migrations from …
the evolutionary history of anatomically modern humans. However, historic migrations from …
[HTML][HTML] Human immunology through the lens of evolutionary genetics
L Quintana-Murci - Cell, 2019 - cell.com
Pathogen-imposed selection pressures have been paramount during human evolution.
Detecting such selection signatures in ancient and modern human genomes can thus help …
Detecting such selection signatures in ancient and modern human genomes can thus help …