Epigenetic modifications are heritable changes in gene expression not encoded by the DNA
sequence. In the past decade, great strides have been made in characterizing epigenetic …

Plasticity in developmental programming has evolved in order to provide the best chances of
survival and reproductive success to the organism under changing environments …

Rationale: DNA methylation is an important epigenetic mechanism, which often occurs in
response to environmental stimuli and is crucial in regulating gene expression. It is likely …

Accurate read-out of chromatin modifications is essential for eukaryotic life. Mutations in the
gene encoding X-linked ATRX protein cause a mental-retardation syndrome, whereas wild …

One of the most fundamental questions in the control of gene expression in mammals is how
epigenetic methylation patterns of DNA and histones are established, erased, and …

The prognosis of lung cancer patients with different clinical stages is significantly different.
The 5-year survival of stage IA groups can exceed 90%, while patients with stage IV can be …

Epigenetics focuses on DNA methylation, histone modification, chromatin remodeling,
noncoding RNAs, and other gene regulation mechanisms beyond the DNA sequence. In the …

Epigenetic marks change during fetal development, adult life, and aging. Some changes
play an important role in the establishment and regulation of gene programs, but others …

It has been widely speculated that epigenetic changes may play a role in the etiology of
psychotic illnesses such as schizophrenia and bipolar disorder. Epigenetics is the study of …

High risk human papillomaviruses are squamous epitheliotropic viruses that may cause
cervical and other cancers. HPV replication depends on squamous epithelial differentiation …