Pain has been considered as a concept of sensation that we feel as a reaction to the
stimulus of our surrounding, putting us in harm's way and acting as a form of defense …

Background There is an unmet need of pharmacological and non-pharmacological
treatment options for migraine patients. Exercise can be used in the treatment of several …

The cellular and molecular mechanisms mediating histamine-independent itch in primary
sensory neurons are largely unknown. Itch induced by chloroquine (CQ) is a common side …

Hayes' Principles and Methods of Toxicology has long been established as a reliable and
informative reference for the concepts, methodologies, and assessments integral to …

Objective We aimed (1) to analyze salivary calcitonin gene‐related peptide (CGRP) levels in
patients with migraine,(2) to predict erenumab response from baseline CGRP levels, and (3) …

Calcitonin gene‐related peptide (CGRP) is a key mediator in primary headaches including
migraine. Animal models of meningeal nociception demonstrate both peripheral and central …

Background: The neuropeptide calcitonin gene-related peptide (CGRP) plays a key role in
migraine pathophysiology. In this large phase 3 clinical trial, we sought to confirm the …

Migraine is a highly prevalent neurovascular disorder that can be provoked by infusion of
calcitonin gene-related peptide (CGRP). CGRP, a neuropeptide released from activated …

Objective Identification of the neural mechanisms underlying medication overuse headache
resulting from triptans. Methods Triptans were administered systemically to rats by repeated …

Adrenomedullin (AM) is a peptide involved both in the pathogenesis of cardiovascular
diseases and in circulatory homeostasis. The high-affinity AM receptor is composed of …