In human in-vitro fertilization (IVF) embryos are routinely transferred to the uterus on day 2 or
day 3 of development. Resultant implantation and pregnancy rates are disappointingly low …

The molecular basis of many forms of male infertility is poorly defined. One area of research
that has been studied intensely is the integrity of the DNA in the nucleus of mature …

During early mammalian embryogenesis, changes in cell growth and proliferation depend
on strict genetic and metabolic instructions. However, our understanding of metabolic …

Oocyte and embryo metabolism are closely linked with their subsequent developmental
capacity. Lipids are a potent source of cellular energy, yet little is known about lipid …

Summary O-linked-N-acetylglucosamine (O-GlcNAc) has emerged as a critical regulator of
diverse cellular processes, but its role in embryonic stem cells (ESCs) and pluripotency has …

BACKGROUND The advances in the world of IVF during the last decades have been rapid
and impressive and culture media play a major role in this success. Until the 1980s fertility …

Objective To determine the levels of metabolites surrounding the human oocyte and embryo
in vivo. Design Oviduct and uterine fluids were collected throughout the menstrual cycle …

Along with the transition from maternal to embryonic genome control the mammalian
preimplantation embryo undergoes significant changes in its physiology during …

The first edition of the Textbook of Assisted Reproductive Techniques was published in
2001. As the textbook now enters its sixth edition, some 45 years since the birth of Louise …

Considerable advances in media development for the culture of preimplantation mammalian
embryos have been made since mouse embryos were first cultured and successfully …