The discovery of the CRISPR/Cas genome-editing system has revolutionized our
understanding of the plant genome. CRISPR/Cas has been used for over a decade to …

Base editors have substantial promise in basic research and as therapeutic agents for the
correction of pathogenic mutations. The development of adenine transversion editors has …

Highlights●Adapting new nucleases and improving established ones expand the
CRISPR/Cas toolbox.●Optimized base editors enlarge editing windows and enable CG …

Dear Editor, 31 Crop genetic diversity and elite agronomic traits are mainly caused by
genetic variants, 32 of which approximately half are single-nucleotide polymorphisms …

Base editors of the Cas9 system have been widely used for precise nucleotide substitution
in crops. In this study, Cas12a was applied to construct plant cytosine base editors (CBEs) …

Plant metabolism and development are a reflection of the orderly expression of genetic
information intertwined with the environment interactions. Genome editing is the cornerstone …

Base editor (BE) is a gene-editing tool developed by combining the CRISPR/Cas system
with an individual deaminase, enabling precise single-base substitution in DNA or RNA …

Cytosine and adenosine base editors (CBE and ABE) have been widely used in plants,
greatly accelerating gene function research and crop breeding. Current base editors can …

Recently, new types of base editors, C-to-G base editors (CGBEs), that enable cytosine
transversions that are unachievable with cytosine base editors (CBEs) and adenosine base …

Base editors, including cytosine and adenine base editors (CBE and ABE), are promising
tools for precise genome modification. They enable the generation of single nucleotide …