Structure of the shutdown state of myosin-2

CA Scarff, G Carrington, D Casas-Mao, JM Chalovich… - Nature, 2020 - nature.com
Myosin-2 is essential for processes as diverse as cell division and muscle contraction.
Dephosphorylation of its regulatory light chain promotes an inactive,'shutdown'state with the …

[HTML][HTML] Architecture of symbiotic dinoflagellate photosystem I–light-harvesting supercomplex in Symbiodinium

LS Zhao, N Wang, K Li, CY Li, JP Guo, FY He… - Nature …, 2024 - nature.com
Symbiodinium are the photosynthetic endosymbionts for corals and play a vital role in
supplying their coral hosts with photosynthetic products, forming the nutritional foundation …

[HTML][HTML] Structural basis of substrate recognition and translocation by human very long-chain fatty acid transporter ABCD1

ZP Chen, D Xu, L Wang, YX Mao, Y Li… - Nature …, 2022 - nature.com
Human ABC transporter ABCD1 transports very long-chain fatty acids from cytosol to
peroxisome for β-oxidation, dysfunction of which usually causes the X-linked …

[HTML][HTML] Mechanism of glycogen synthase inactivation and interaction with glycogenin

L Marr, D Biswas, LA Daly, C Browning… - Nature …, 2022 - nature.com
Glycogen is the major glucose reserve in eukaryotes, and defects in glycogen metabolism
and structure lead to disease. Glycogenesis involves interaction of glycogenin (GN) with …

[HTML][HTML] Transport mechanism of human bilirubin transporter ABCC2 tuned by the inter-module regulatory domain

YX Mao, ZP Chen, L Wang, J Wang, CZ Zhou… - Nature …, 2024 - nature.com
Bilirubin is mainly generated from the breakdown of heme when red blood cells reach the
end of their lifespan. Accumulation of bilirubin in human body usually leads to various …

[HTML][HTML] Cryo-EM structures of an insecticidal Bt toxin reveal its mechanism of action on the membrane

MJ Byrne, MG Iadanza, MA Perez, DP Maskell… - Nature …, 2021 - nature.com
Insect pests are a major cause of crop losses worldwide, with an estimated economic cost of
$470 billion annually. Biotechnological tools have been introduced to control such insects …

Structural and functional insights into oligopeptide acquisition by the RagAB transporter from Porphyromonas gingivalis

M Madej, JBR White, Z Nowakowska, S Rawson… - Nature …, 2020 - nature.com
Porphyromonas gingivalis, an asaccharolytic member of the Bacteroidetes, is a keystone
pathogen in human periodontitis that may also contribute to the development of other …

[HTML][HTML] Structural analysis of phosphoribosyltransferase-mediated cell wall precursor synthesis in Mycobacterium tuberculosis

S Gao, F Wu, SS Gurcha, SM Batt, GS Besra… - Nature …, 2024 - nature.com
Abstract In Mycobacterium tuberculosis, Rv3806c is a membrane-bound
phosphoribosyltransferase (PRTase) involved in cell wall precursor production. It catalyses …

[HTML][HTML] Structure and dynamics of an archetypal DNA nanoarchitecture revealed via cryo-EM and molecular dynamics simulations

K Ahmad, A Javed, C Lanphere, PV Coveney… - Nature …, 2023 - nature.com
DNA can be folded into rationally designed, unique, and functional materials. To fully realise
the potential of these DNA materials, a fundamental understanding of their structure and …

[HTML][HTML] Insights into the modulation of bacterial NADase activity by phage proteins

H Yin, X Li, X Wang, C Zhang, J Gao, G Yu… - Nature …, 2024 - nature.com
Abstract The Silent Information Regulator 2 (SIR2) protein is widely implicated in antiviral
response by depleting the cellular metabolite NAD+. The defense-associated sirtuin 2 …