Structure of the shutdown state of myosin-2
CA Scarff, G Carrington, D Casas-Mao, JM Chalovich… - Nature, 2020 - nature.com
Myosin-2 is essential for processes as diverse as cell division and muscle contraction.
Dephosphorylation of its regulatory light chain promotes an inactive,'shutdown'state with the …
Dephosphorylation of its regulatory light chain promotes an inactive,'shutdown'state with the …
[HTML][HTML] Architecture of symbiotic dinoflagellate photosystem I–light-harvesting supercomplex in Symbiodinium
LS Zhao, N Wang, K Li, CY Li, JP Guo, FY He… - Nature …, 2024 - nature.com
Symbiodinium are the photosynthetic endosymbionts for corals and play a vital role in
supplying their coral hosts with photosynthetic products, forming the nutritional foundation …
supplying their coral hosts with photosynthetic products, forming the nutritional foundation …
[HTML][HTML] Structural basis of substrate recognition and translocation by human very long-chain fatty acid transporter ABCD1
Human ABC transporter ABCD1 transports very long-chain fatty acids from cytosol to
peroxisome for β-oxidation, dysfunction of which usually causes the X-linked …
peroxisome for β-oxidation, dysfunction of which usually causes the X-linked …
[HTML][HTML] Mechanism of glycogen synthase inactivation and interaction with glycogenin
Glycogen is the major glucose reserve in eukaryotes, and defects in glycogen metabolism
and structure lead to disease. Glycogenesis involves interaction of glycogenin (GN) with …
and structure lead to disease. Glycogenesis involves interaction of glycogenin (GN) with …
[HTML][HTML] Transport mechanism of human bilirubin transporter ABCC2 tuned by the inter-module regulatory domain
YX Mao, ZP Chen, L Wang, J Wang, CZ Zhou… - Nature …, 2024 - nature.com
Bilirubin is mainly generated from the breakdown of heme when red blood cells reach the
end of their lifespan. Accumulation of bilirubin in human body usually leads to various …
end of their lifespan. Accumulation of bilirubin in human body usually leads to various …
[HTML][HTML] Cryo-EM structures of an insecticidal Bt toxin reveal its mechanism of action on the membrane
MJ Byrne, MG Iadanza, MA Perez, DP Maskell… - Nature …, 2021 - nature.com
Insect pests are a major cause of crop losses worldwide, with an estimated economic cost of
$470 billion annually. Biotechnological tools have been introduced to control such insects …
$470 billion annually. Biotechnological tools have been introduced to control such insects …
Structural and functional insights into oligopeptide acquisition by the RagAB transporter from Porphyromonas gingivalis
Porphyromonas gingivalis, an asaccharolytic member of the Bacteroidetes, is a keystone
pathogen in human periodontitis that may also contribute to the development of other …
pathogen in human periodontitis that may also contribute to the development of other …
[HTML][HTML] Structural analysis of phosphoribosyltransferase-mediated cell wall precursor synthesis in Mycobacterium tuberculosis
Abstract In Mycobacterium tuberculosis, Rv3806c is a membrane-bound
phosphoribosyltransferase (PRTase) involved in cell wall precursor production. It catalyses …
phosphoribosyltransferase (PRTase) involved in cell wall precursor production. It catalyses …
[HTML][HTML] Structure and dynamics of an archetypal DNA nanoarchitecture revealed via cryo-EM and molecular dynamics simulations
K Ahmad, A Javed, C Lanphere, PV Coveney… - Nature …, 2023 - nature.com
DNA can be folded into rationally designed, unique, and functional materials. To fully realise
the potential of these DNA materials, a fundamental understanding of their structure and …
the potential of these DNA materials, a fundamental understanding of their structure and …
[HTML][HTML] Insights into the modulation of bacterial NADase activity by phage proteins
H Yin, X Li, X Wang, C Zhang, J Gao, G Yu… - Nature …, 2024 - nature.com
Abstract The Silent Information Regulator 2 (SIR2) protein is widely implicated in antiviral
response by depleting the cellular metabolite NAD+. The defense-associated sirtuin 2 …
response by depleting the cellular metabolite NAD+. The defense-associated sirtuin 2 …