The BRCA1-A complex contains matching lysine-63 ubiquitin (K63-Ub) binding and
deubiquitylating activities. How these functionalities are coordinated to effectively respond to …

The transmembrane voltage gradient is a general physico-chemical cue that regulates
diverse biological function through voltage-gated ion channels. How voltage sensing …

Cryo-electron microscopy (cryo-EM) is capable of producing reconstructed 3D images of
biomolecules at near-atomic resolution. However, raw cryo-EM images are only highly …

Acinetobacter baumannii is a Gram-negative bacterium primarily associated with hospital-
acquired, often multidrug-resistant (MDR) infections. The ribosome-targeting antibiotics …

The production of plant helical virus-like particles (VLPs) via plant-based expression has
been problematic with previous studies suggesting that an RNA scaffold may be necessary …

Single-particle cryo-electron microscopy (cryoEM) provides an attractive avenue for
advancing our atomic resolution understanding of materials, molecules and living systems …

Coordinated carbon and nitrogen metabolism is crucial for bacteria living in the fluctuating
environments. Intracellular carbon and nitrogen homeostasis is maintained by a …

The RNA-targeting type VI CRISPR-Cas effector complexes are widely used in
biotechnology applications such as gene knockdown, RNA editing, and molecular …

ABCB10, a member of ABC transporter superfamily that locates in the inner membrane of
mitochondria, plays crucial roles in hemoglobin synthesis, antioxidative stress and …

Advances in single particle cryo-EM data collection and processing have seen a significant
rise in its use. However, the influences of the environment generated through grid …