Beta-lactam antibiotics remain one of the most preferred groups of antibiotics in critical care
due to their excellent safety profiles and their activity against a wide spectrum of pathogens …

Infections are important factors contributing to the morbidity and mortality among elderly
patients. High rates of consumption of antimicrobial agents by the elderly may result in …

Background: Therapeutic drug monitoring (TDM) may be helpful in tailoring treatment with
antimicrobials, and expert interpretation of the results may make it more clinically useful …

Objectives Therapeutic drug monitoring (TDM) may be helpful in tailoring antimicrobial
treatment, and expert interpretation of the results may make it more clinically useful. Methods …

Background Optimal β-lactam dosing for the treatment of Gram-negative bacteria
bloodstream infections (GNB-BSIs) remains a debated issue. Herein, the efficacy and safety …

What is known and objective Timely and appropriate dosing of antibiotics is essential for the
treatment of bacterial sepsis. Critically ill patients treated with continuous kidney …

Piperacillin/tazobactam (TZP) is administered intravenously in a fixed ratio (8: 1) with the
potential for inadequate tazobactam exposure to ensure piperacillin activity against …

The present study aimed to explore the population pharmacokinetics and initial dose
optimization of tacrolimus in children with severe combined immunodeficiency (SCID) …

Introduction Older individuals face an elevated risk of developing bacterial infections. The
optimal use of antibacterial agents in this population is challenging because of age-related …

Background and objective (Patho) physiological changes in older people may influence the
pharmacokinetics (PK), and consequently the target attainment, of ß-lactam antibiotics using …