Cardiac remodeling—concepts and clinical implications: a consensus paper from an international forum on cardiac remodeling

JN Cohn, R Ferrari, N Sharpe… - Journal of the American …, 2000 - jacc.org
Cardiac remodeling is generally accepted as a determinant of the clinical course of heart
failure (HF). Defined as genome expression resulting in molecular, cellular and interstitial …

Myocardial matrix remodeling and the matrix metalloproteinases: influence on cardiac form and function

FG Spinale - Physiological reviews, 2007 - journals.physiology.org
It is now becoming apparent that dynamic changes occur within the interstitium that directly
contribute to adverse myocardial remodeling following myocardial infarction (MI), with …

Molecular pathways underlying cardiac remodeling during pathophysiological stimulation

I Kehat, JD Molkentin - Circulation, 2010 - Am Heart Assoc
Cardiac remodeling involves molecular, cellular, and in-terstitial changes that manifest
clinically as changes in size, shape, and function of the heart after injury or stress …

Mechanical unloading in heart failure

N Uriel, G Sayer, S Annamalai, NK Kapur… - Journal of the American …, 2018 - jacc.org
Myocardial injury induces significant changes in ventricular structure and function at both the
cellular and anatomic level, leading to ventricular remodeling and subsequent heart failure …

Cardiac remodelling: concentric versus eccentric hypertrophy in strength and endurance athletes

C Mihl, WRM Dassen, H Kuipers - Netherlands Heart Journal, 2008 - Springer
Cardiac remodelling is commonly defined as a physiological or pathological state that may
occur after conditions such as myocardial infarction, pressure overload, idiopathic dilated …

Magnetic resonance myocardial fiber-orientation mapping with direct histological correlation

EW Hsu, AL Muzikant… - American Journal …, 1998 - journals.physiology.org
Functional properties of the myocardium are mediated by the tissue structure. Consequently,
proper physiological studies and modeling necessitate a precise knowledge of the fiber …

Remodeling of the myocardium and potential targets in the collagen degradation and synthesis pathways

BI Jugdutt - Current Drug Targets-Cardiovascular & …, 2003 - ingentaconnect.com
Remodeling of the myocardium is the major mechanism for disability and death in prevalent
cardiovascular diseases such as hypertension, heart failure and myocardial infarction (MI). It …

Increased myocardial apoptosis in patients with unfavorable left ventricular remodeling and early symptomatic post-infarction heart failure

A Abbate, GGL Biondi-Zoccai, R Bussani… - Journal of the American …, 2003 - jacc.org
Objectives: The purpose of this study was to evaluate a potential correlation between
apoptotic rate (AR), post-infarction left ventricular (LV) remodeling, and clinical …

Ventricular arrhythmias in ischemic cardiomyopathy—New avenues for mechanism-guided treatment

M Amoni, E Dries, S Ingelaere, D Vermoortele… - Cells, 2021 - mdpi.com
Ischemic heart disease is the most common cause of lethal ventricular arrhythmias and
sudden cardiac death (SCD). In patients who are at high risk after myocardial infarction …

Pathophysiologic role of myocardial apoptosis in post‐infarction left ventricular remodeling

A Abbate, GGL Biondi‐Zoccai… - Journal of cellular …, 2002 - Wiley Online Library
Left ventricular (LV) remodeling and heart failure (HF) complicate acute myocardial
infarction (AMI) even weeks to months after the initial insult. Apoptosis may represent an …