Pharmacotherapy of type 2 diabetes: An update and future directions

A DeMarsilis, N Reddy, C Boutari, A Filippaios… - Metabolism, 2022 - Elsevier
Abstract Type 2 diabetes (T2D) is a widely prevalent disease with substantial economic and
social impact for which multiple conventional and novel pharmacotherapies are currently …

Ferroptosis, a new pathogenetic mechanism in cardiometabolic diseases and cancer: Is there a role for statin therapy?

A Sahebkar, Z Foroutan, N Katsiki, T Jamialahmadi… - Metabolism, 2023 - Elsevier
One of the newly recognized types of cell death is ferroptosis which is related to the
accumulation of iron and lipid-reactive oxygen species. Ferroptosis is considered a …

From non-alcoholic fatty liver disease (NAFLD) to steatotic liver disease (SLD): an ongoing journey towards refining the terminology for this prevalent metabolic …

M Kokkorakis, C Boutari, N Katsiki… - Metabolism-Clinical …, 2023 - metabolismjournal.com
Non-alcoholic fatty liver disease (NAFLD) is a prevalent metabolic condition closely
associated with genetic predisposition and/or obesity, lipodystrophy, and insulin resistance …

Glucagon-like peptide-1 receptor agonists and dual glucose-dependent insulinotropic polypeptide/glucagon-like peptide-1 receptor agonists in the treatment of …

EM Muzurović, Š Volčanšek… - Journal of …, 2022 - journals.sagepub.com
The obesity pandemic is accompanied by increased risk of developing metabolic syndrome
(MetS) and related conditions: non-alcoholic fatty liver disease (NAFLD)/non-alcoholic …

Steatotic liver disease: pathophysiology and emerging pharmacotherapies

M Kokkorakis, E Muzurović, Š Volčanšek… - Pharmacological …, 2024 - ASPET
Steatotic liver disease (SLD) displays a dynamic and complex disease phenotype.
Consequently, the metabolic dysfunction-associated steatotic liver disease …

Resmetirom, the first approved drug for the management of metabolic dysfunction-associated steatohepatitis: trials, opportunities, and challenges

M Kokkorakis, C Boutari, MA Hill… - Metabolism …, 2024 - metabolismjournal.com
Over the past decade, there have been several guideline updates for the diagnosis and
management of non-alcoholic fatty liver disease (NAFLD), which is the most common …

Precision medicine in fatty liver disease/non-alcoholic fatty liver disease

L Valenzuela-Vallejo, D Sanoudou… - Journal of Personalized …, 2023 - mdpi.com
Non-alcoholic fatty liver disease (NAFLD) is the most prevalent chronic liver disease, and is
related to fatal and non-fatal liver, metabolic, and cardiovascular complications. Its non …

Safety and efficacy of once-daily HU6 versus placebo in people with non-alcoholic fatty liver disease and high BMI: a randomised, double-blind, placebo-controlled …

M Noureddin, S Khan, F Portell, D Jorkasky… - The Lancet …, 2023 - thelancet.com
Background HU6 is a controlled metabolic accelerator that is metabolised in the liver to the
mitochondrial uncoupler 2, 4-dinitrophenol and increases substrate utilisation so that fat and …

Circulating hormones in biopsy-proven steatotic liver disease and steatohepatitis: A Multicenter Observational Study

L Valenzuela-Vallejo, P Chrysafi, M Kouvari… - Metabolism, 2023 - Elsevier
Background The role of metabolic/inflammatory hormonal systems in metabolic dysfunction
associated steatotic liver disease (MASLD) remains to be fully elucidated. Purpose To report …

The effects of sodium-glucose cotransporter 2-inhibitors on steatosis and fibrosis in patients with non-alcoholic fatty liver disease or steatohepatitis and type 2 diabetes …

IC Bica, RA Stoica, T Salmen, A Janež, Š Volčanšek… - Medicina, 2023 - mdpi.com
Type 2 Diabetes Mellitus (T2DM) and non-alcoholic fatty liver disease (NAFLD) are part of
metabolic syndrome and share multiple causal associations. Both conditions have an …