CircRNAs, covalently closed noncoding RNAs, are widely expressed in a wide range of
species ranging from viruses to plants to mammals. CircRNAs were enriched in the Wnt …

Cancer cells resistance to various therapies remains to be a key challenge nowadays. For a
long time, scientists focused on tumor cells themselves for the mechanisms of acquired drug …

Platelets have been hypothesized to promote certain neoplastic malignancies; however,
antiplatelet drugs are still not part of routine pharmacological cancer prevention and …

The main role of platelets is to control bleeding and repair vascular damage via thrombosis.
They have also been implicated to promote tumor metastasis through platelet-tumor cell …

Pancreatic ductal adenocarcinoma (PDAC) is a solid malignant tumor with a very low
operative rate and a poor patient prognosis. Therefore, gemcitabine (GEM)-based …

The canonical role of platelets as central players in cardiovascular disease by way of their
fundamental role in mediating thrombosis and haemostasis is well appreciated. However …

Distant spreading of metastatic tumor cells is still the leading cause of tumor death.
Metastatic spreading is a complex process, in which epithelial-mesenchymal transition …

Platelet function can be modified by cancer cells to support tumor growth, causing
alterations in the delicate hemostatic equilibrium. Cancer-cell and platelet interactions are …

Platelets have been recognized as key players in hemostasis, thrombosis, and cancer.
Preclinical and clinical researches evidenced that tumorigenesis and metastasis can be …

Spontaneous venous thrombosis is often the first clinical sign of cancer, and it is linked to a
worsened survival rate. Traditionally, tumor-cell induced platelet activation has been the …