Taxanes in cancer treatment: Activity, chemoresistance and its overcoming
Since 1984, when paclitaxel was approved by the FDA for the treatment of advanced
ovarian carcinoma, taxanes have been widely used as microtubule-targeting antitumor …
ovarian carcinoma, taxanes have been widely used as microtubule-targeting antitumor …
Natural products as multidrug resistance modulators in cancer
Cancer is a prominent cause of death globally. Currently, many drugs that are in clinical
practice are having a high prevalence of side effect and multidrug resistance. Risk of tumors …
practice are having a high prevalence of side effect and multidrug resistance. Risk of tumors …
TFAP2C-mediated lncRNA PCAT1 inhibits ferroptosis in docetaxel-resistant prostate cancer through c-Myc/miR-25-3p/SLC7A11 signaling
X Jiang, S Guo, M Xu, B Ma, R Liu, Y Xu… - Frontiers in …, 2022 - frontiersin.org
Recent evidence has shown that the induction of ferroptosis is a new therapeutic strategy for
advanced prostate cancer (PCa) when used as a monotherapy or in combination with …
advanced prostate cancer (PCa) when used as a monotherapy or in combination with …
PI3K-AKT-mTOR and NFκB pathways in ovarian cancer: implications for targeted therapeutics
Ovarian cancer is the most lethal gynecologic malignancy in the United States, with an
estimated 22,530 new cases and 13,980 deaths in 2019. Recent studies have indicated that …
estimated 22,530 new cases and 13,980 deaths in 2019. Recent studies have indicated that …
Mechanisms of taxane resistance
SM Maloney, CA Hoover, LV Morejon-Lasso… - Cancers, 2020 - mdpi.com
Simple Summary Drug resistance is prevalent in many types of cancer and decreases
patient survival. The taxanes are anti-mitotic chemotherapeutic agents, widely used since …
patient survival. The taxanes are anti-mitotic chemotherapeutic agents, widely used since …
Docetaxel: An update on its molecular mechanisms, therapeutic trajectory and nanotechnology in the treatment of breast, lung and prostate cancer
Amongst the various microtubule-targeting agents, Docetaxel (DTX) has gained immense
attention in cancer chemotherapy due to its good therapeutic index. DTX belongs to the …
attention in cancer chemotherapy due to its good therapeutic index. DTX belongs to the …
Current and emerging therapies for neuroendocrine prostate cancer
Neuroendocrine prostate cancer is a histological variant of prostate cancer that is
characterized by aggressiveness, poor clinical outcomes, and expression of neuroendocrine …
characterized by aggressiveness, poor clinical outcomes, and expression of neuroendocrine …
The breast cancer stem cells traits and drug resistance
Drug resistance is a major challenge in breast cancer (BC) treatment at present.
Accumulating studies indicate that breast cancer stem cells (BCSCs) are responsible for the …
Accumulating studies indicate that breast cancer stem cells (BCSCs) are responsible for the …
Role of noncoding RNA in drug resistance of prostate cancer
L Ding, R Wang, D Shen, S Cheng, H Wang, Z Lu… - Cell death & …, 2021 - nature.com
Prostate cancer is one of the most prevalent forms of cancer around the world. Androgen-
deprivation treatment and chemotherapy are the curative approaches used to suppress …
deprivation treatment and chemotherapy are the curative approaches used to suppress …
Combination treatment of docetaxel with caffeic acid phenethyl ester suppresses the survival and the proliferation of docetaxel-resistant prostate cancer cells via …
YK Fu, BJ Wang, JC Tseng, SH Huang, CY Lin… - Journal of biomedical …, 2022 - Springer
Background Docetaxel has been approved by USFDA as a first-line treatment for castration-
resistant prostate cancer (CRPC) patients. Patients receiving androgen deprivation therapy …
resistant prostate cancer (CRPC) patients. Patients receiving androgen deprivation therapy …