The amide functional group plays a key role in the composition of biomolecules, including
many clinically approved drugs. Bioisosterism is widely employed in the rational …

The immune system deploys a multitude of innate and adaptive mechanisms not only to
ward off pathogens but also to prevent malignant transformation (“immune surveillance”) …

Microglial cells, the resident macrophages of the central nervous system (CNS), exist in a
process-bearing, ramified/surveying phenotype under resting conditions. Upon activation by …

Adenosine deaminase (ADA) deficiency leads to an accumulation of toxic purine
degradation by-products, most potently affecting lymphocytes, leading to adenosine …

Adenosine is involved in a range of physiological and pathological effects through
membrane-bound receptors linked to G proteins. There are four subtypes of adenosine …

Alzheimer's disease (AD) is an irreversible, age-related progressive neurological disorder,
and the most common type of dementia in aged people. Neuropathological lesions of AD …

Cordycepin is the major bioactive component extracted from Cordyceps militaris. In recent
years, cordycepin has received increasing attention owing to its multiple pharmacological …

Adenosine receptor subtypes, first described 40 years ago, are known to regulate diverse
biological functions and have a role in various conditions, such as cerebral and cardiac …

Over the last 15 years, the field of neuroscience has evolved toward recognizing the critical
role of astroglia in shaping neuronal synaptic activity and along with the pre-and …

Cordyceps is a genus of ascomycete fungi that has been used for traditional herbal
remedies. It contains various bioactive ingredients including cordycepin. Cordycepin, also …