We now know that cancer is many different diseases, with great variation even within a
single histological subtype. With the current emphasis on developing personalized …

Abstract Development of the retinal vasculature is based on highly coordinated signalling
between different cell types of the retina, integrating internal metabolic requirements with …

Pro-angiogenic factors are key regulators of angiogenesis. Here we report that highly
migratory cells patrol the area of capillary formation in chick embryo chorioallantoic …

The regulation of vascular endothelial growth factor A (VEGF) is critical to
neovascularization in numerous tissues under physiological and pathological conditions …

Peripheral arterial disease (PAD) is caused by occlusive atherosclerosis in a vascular bed
other than the heart. The lower extremity is the most-common location for PAD. Critical limb …

Blood travels throughout the body in an extensive network of vessels–arteries, veins and
capillaries. This vascular network is not static, but instead dynamically remodels in response …

Pericellular proteases have long been associated with cancer invasion and metastasis due
to their ability to degrade extracellular matrix components. Recent studies demonstrate that …

Integration of data across spatial, temporal, and functional scales is a primary focus of
biomedical engineering efforts. The advent of powerful computing platforms, coupled with …

Abstract Vascular Endothelial Growth Factor A (VEGF-A) is a potent secreted mitogen crucial
for physiological and pathological angiogenesis. Post-transcriptional regulation of VEGF-A …

Despite extensive research, pro-angiogenic drugs have failed to translate clinically, and
therapeutic angiogenesis, which has potential in the treatment of various cardiovascular …