BACKGROUND: Although the clinical and health economic characteristics of commercially
insured adults with treatment-resistant depression (TRD) have been well characterized, little …

Abstract Background Major depressive disorders (MDDs) including treatment-resistant
depression (TRD) are common disabling conditions, but data on their epidemiology in …

Background and aims Treatment‐resistant depression (TRD), defined as inadequate
treatment response after at least two adequate treatment trials, is common among patients …

Background Several definitions of treatment-resistant depression (TRD) are used for clinical
research, but no verified model for use in register data exists. We aimed to compare a novel …

Treatment-Resistant Depression (TRD) affects 60 to 70% of patients with Major Depressive
Disorder (MDD). The economic impact of depression in general, and of TRD specifically …

Background The incidence and burden of depressive disorders are increasing in South
Korea. There are many differences between pharmaceutically treated depression (PTD) and …

OBJECTIVE: Major Depressive Disorder (MDD) is a debilitating condition with a marked
social impact. The impact of MDD and Treatment-Resistant Depression (TRD+) within the …

Rationale Therapeutic administration of psychedelics has shown significant potential in
historical accounts and recent clinical trials in the treatment of depression and other mood …

Despite the large number of depressed patients who do not respond to first-line
antidepressants, the evidence base of alternate strategies is quite thin. In this article, a …

Background Depression is associated with excess mortality, but it is not known how
treatment-resistance influences life expectancy. We estimated cause-specific excess …