Human genetic and immunological determinants of critical COVID-19 pneumonia

Q Zhang, P Bastard, A Cobat, JL Casanova - Nature, 2022 - nature.com
SARS-CoV-2 infection is benign in most individuals but, in around 10% of cases, it triggers
hypoxaemic COVID-19 pneumonia, which leads to critical illness in around 3% of cases …

Effectiveness and safety of SARS-CoV-2 vaccine in real-world studies: a systematic review and meta-analysis

Q Liu, C Qin, M Liu, J Liu - Infectious diseases of poverty, 2021 - mednexus.org
Background: To date, coronavirus disease 2019 (COVID-19) becomes increasingly fierce
due to the emergence of variants. Rapid herd immunity through vaccination is needed to …

Omicron and Delta variant of SARS‐CoV‐2: a comparative computational study of spike protein

S Kumar, TS Thambiraja, K Karuppanan… - Journal of medical …, 2022 - Wiley Online Library
Emerging severe acute respiratory syndrome coronavirus type 2 (SARS‐CoV‐2) variants,
especially those of concern, may have an impact on the virus's transmissibility and …

[HTML][HTML] Global emerging Omicron variant of SARS-CoV-2: Impacts, challenges and strategies

K Dhama, F Nainu, A Frediansyah, MI Yatoo… - Journal of infection and …, 2023 - Elsevier
Newly emerging variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
are continuously posing high global public health concerns and panic resulting in waves of …

COVID-19 vaccines in patients with cancer: immunogenicity, efficacy and safety

A Fendler, EGE de Vries… - Nature Reviews …, 2022 - nature.com
Patients with cancer have a higher risk of severe coronavirus disease (COVID-19) and
associated mortality than the general population. Owing to this increased risk, patients with …

The evolution and biology of SARS-CoV-2 variants

A Telenti, EB Hodcroft… - Cold Spring …, 2022 - perspectivesinmedicine.cshlp.org
Our understanding of the still unfolding severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) pandemic would have been extremely limited without the study of the …

COVID-19 in people with rheumatic diseases: risks, outcomes, treatment considerations

R Grainger, AHJ Kim, R Conway, J Yazdany… - Nature Reviews …, 2022 - nature.com
The COVID-19 pandemic has brought challenges for people with rheumatic disease in
addition to those faced by the general population, including concerns about higher risks of …

Disentangling the relative importance of T cell responses in COVID-19: leading actors or supporting cast?

SJ Kent, DS Khoury, A Reynaldi, JA Juno… - Nature Reviews …, 2022 - nature.com
The rapid development of multiple vaccines providing strong protection from severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has been a major achievement …

A critical overview of current progress for COVID-19: development of vaccines, antiviral drugs, and therapeutic antibodies

M Kumari, RM Lu, MC Li, JL Huang, FF Hsu… - Journal of biomedical …, 2022 - Springer
The novel coronavirus disease (COVID-19) pandemic remains a global public health crisis,
presenting a broad range of challenges. To help address some of the main problems, the …

Molecular mechanisms of SARS-CoV-2 resistance to nirmatrelvir

Y Duan, H Zhou, X Liu, S Iketani, M Lin, X Zhang… - Nature, 2023 - nature.com
Nirmatrelvir is a specific antiviral drug that targets the main protease (Mpro) of SARS-CoV-2
and has been approved to treat COVID-19,. As an RNA virus characterized by high mutation …