Background Non-alcoholic fatty liver disease, or as recently proposed 'metabolic-associated
fatty liver disease'(MAFLD), is characterized by pathological accumulation of triglycerides …

Triglyceride molecules represent the major form of storage and transport of fatty acids within
cells and in the plasma. The liver is the central organ for fatty acid metabolism. Fatty acids …

Long-chain fatty acyl-coenzyme As (CoAs) are critical regulatory molecules and metabolic
intermediates. The initial step in their synthesis is the activation of fatty acids by one of 13 …

The cellular uptake of free fatty acids (FFA) is followed by esterification to coenzyme A
(CoA), generating fatty acyl-CoAs that are substrates for oxidation or incorporation into …

Long-chain fatty acyl-CoA esters are key intermediates in numerous lipid metabolic
pathways, and recognized as important cellular signaling molecules. The intracellular flux …

Until recently, intracellular triacylglycerols (TAG) stored in the form of cytoplasmic lipid
droplets have been considered to be only passive “energy conserves”. Nevertheless …

Acyl-CoA formation initiates cellular fatty acid metabolism. Acyl-CoAs are generated by the
ligation of a fatty acid to Coenzyme A mediated by a large family of acyl-CoA synthetases …

Hepatic lipid metabolism is highly dynamic, and disruption of several circadian
transcriptional regulators results in hepatic steatosis. This includes genetic disruption of the …

Phosphatidylcholine transfer protein (PC-TP; synonym StarD2) is a soluble lipid-binding
protein that transports phosphatidylcholine (PC) between cellular membranes. To better …

Numerous neurological diseases are associated with dysregulated lipid metabolism;
however, the basic metabolic control of fatty acid metabolism in neurons remains enigmatic …