Inflammation is an essential action to protect the host human body from external, harmful
antigens and microorganisms. However, an excessive inflammation reaction sometimes …

Throughout life, it is necessary to adapt to the Earth's environment in order to survive. A
typical example of this is that the daily Earth cycle is different from the circadian rhythm in …

Key research advances in atopic dermatitis (AD) suggest the complexity of its endotypes. A
comprehensive serum biomarker panel revealed at least 4 types of AD. Some represent …

Alopecia areata is a representative inflammatory skin disease that is associated with various
environmental stimuli. While psychological stress is believed to be a major pathogenetic …

Selective modulation of the heterotrimeric G protein α S subunit–coupled prostaglandin E2
(PGE2) receptor EP2 subtype is a promising therapeutic strategy for osteoporosis, ocular …

Prostaglandins are derived from arachidonic acid metabolism through cyclooxygenase
activities. Among prostaglandins (PGs), prostacyclin (PGI2) and PGE2 are strongly involved …

Humans are exposed to various external environmental factors. Food intake is one of the
most influential factors impacting daily lifestyle. Among nutrients obtained from foods, omega …

Prostanoids and leukotrienes (LTs) are representative of ω6 fatty acid‐derived metabolites
that exert their actions through specific receptors on the cell surface. These lipid mediators …

Daily lifestyle is a fundamental part of human life and its influence accumulates daily in the
human body. We observe that a good daily lifestyle has a beneficial impact on our health; …

Lipids play fundamental roles in life as an essential component of cell membranes, as a
major source of energy, as a body surface barrier, and as signaling molecules that transmit …