Mechanisms of action and regulation of ATP-dependent chromatin-remodelling complexes
Cells utilize diverse ATP-dependent nucleosome-remodelling complexes to carry out
histone sliding, ejection or the incorporation of histone variants, suggesting that different …
histone sliding, ejection or the incorporation of histone variants, suggesting that different …
Causes and consequences of RNA polymerase II stalling during transcript elongation
M Noe Gonzalez, D Blears, JQ Svejstrup - Nature reviews Molecular …, 2021 - nature.com
The journey of RNA polymerase II (Pol II) as it transcribes a gene is anything but a smooth
ride. Transcript elongation is discontinuous and can be perturbed by intrinsic regulatory …
ride. Transcript elongation is discontinuous and can be perturbed by intrinsic regulatory …
The DNA damage response to transcription stress
The spatiotemporal control of RNA polymerase II (Pol II)-mediated gene transcription is
tightly and intricately regulated. In addition, preservation of the integrity of the DNA template …
tightly and intricately regulated. In addition, preservation of the integrity of the DNA template …
Understanding nucleotide excision repair and its roles in cancer and ageing
JA Marteijn, H Lans, W Vermeulen… - … reviews Molecular cell …, 2014 - nature.com
Nucleotide excision repair (NER) eliminates various structurally unrelated DNA lesions by a
multiwise'cut and patch'-type reaction. The global genome NER (GG-NER) subpathway …
multiwise'cut and patch'-type reaction. The global genome NER (GG-NER) subpathway …
Transcription-coupled nucleotide excision repair and the transcriptional response to UV-induced DNA damage
N Nieto Moreno, AM Olthof… - Annual review of …, 2023 - annualreviews.org
Ultraviolet (UV) irradiation and other genotoxic stresses induce bulky DNA lesions, which
threaten genome stability and cell viability. Cells have evolved two main repair pathways to …
threaten genome stability and cell viability. Cells have evolved two main repair pathways to …
Ubiquitination of DNA damage-stalled RNAPII promotes transcription-coupled repair
Y Nakazawa, Y Hara, Y Oka, O Komine… - Cell, 2020 - cell.com
Transcription-coupled nucleotide excision repair (TC-NER) is initiated by the stalling of
elongating RNA polymerase II (RNAPIIo) at DNA lesions. The ubiquitination of RNAPIIo in …
elongating RNA polymerase II (RNAPIIo) at DNA lesions. The ubiquitination of RNAPIIo in …
The biology of chromatin remodeling complexes
CR Clapier, BR Cairns - Annual review of biochemistry, 2009 - annualreviews.org
The packaging of chromosomal DNA by nucleosomes condenses and organizes the
genome, but occludes many regulatory DNA elements. However, this constraint also allows …
genome, but occludes many regulatory DNA elements. However, this constraint also allows …
[HTML][HTML] Regulation of the RNAPII pool is integral to the DNA damage response
In response to transcription-blocking DNA damage, cells orchestrate a multi-pronged
reaction, involving transcription-coupled DNA repair, degradation of RNA polymerase II …
reaction, involving transcription-coupled DNA repair, degradation of RNA polymerase II …
Direct cellular responses to platinum-induced DNA damage
Y Jung, SJ Lippard - Chemical reviews, 2007 - ACS Publications
Since the serendipitous discovery of the biological activity of cisplatin, 1 the drug has been
applied extensively in cancer chemotherapy. 2 Platinum-based drugs such as cisplatin …
applied extensively in cancer chemotherapy. 2 Platinum-based drugs such as cisplatin …
The general transcription machinery and general cofactors
MC Thomas, CM Chiang - Critical reviews in biochemistry and …, 2006 - Taylor & Francis
In eukaryotes, the core promoter serves as a platform for the assembly of transcription
preinitiation complex (PIC) that includes TFIIA, TFIIB, TFIID, TFIIE, TFIIF, TFIIH, and RNA …
preinitiation complex (PIC) that includes TFIIA, TFIIB, TFIID, TFIIE, TFIIF, TFIIH, and RNA …