Metastatic melanoma is hallmarked by its ability of phenotype switching to more slowly
proliferating, but highly invasive cells. Here, we tested the impact of signal transducer and …

Histamine is a critical mediator of IgE/mast cell-mediated anaphylaxis, a neurotransmitter
and a regulator of gastric acid secretion. Histamine is a monoamine synthesized from the …

Myeloid cells are the most abundant cells in the tumor microenvironment (TME). The tumor
recruits and modulates endogenous myeloid cells to tumor-associated macrophages (TAM) …

Basophils are the rarest granulocytes which represent< 1% of peripheral blood leukocytes.
Basophils bear several phenotypic similarities to tissue‐resident mast cells and therefore …

Basophils are the rarest granulocytes and are recognized as critical cells for type 2 immune
responses. However, their differentiation pathway remains to be fully elucidated. Here, we …

Until recently, basophils had often been neglected in immunologic studies because of their
minority status among immune cells or confused with tissue-resident mast cells because of …

Abstract Interferon regulatory factor-8 (IRF8) is a transcription factor expressed in
hematopoietic cells, particularly in mononuclear phagocytes [monocytes/macrophages and …

The mechanism by which inflammasome activation is modulated remains unclear. In this
study, we identified an AIM2-interacting protein, the E3 ubiquitin ligase HUWE1, which was …

Pathogens have co-evolved with mosquitoes to optimize transmission to hosts. Mosquito
salivary-gland extract is known to modulate host immune responses and facilitate pathogen …

Mast cells (MCs) are widely recognized as central effector cells during type 2 inflammatory
reactions and thought to also play a role in innate immune responses, wound healing, and …