Despite advanced understanding of the biology of atherosclerosis, coronary heart disease
remains the leading cause of death worldwide. Progress has been challenging as half of the …

Intravascular ultrasound (IVUS) and optical coherence tomography (OCT) have been
developed and improved as both diagnostic and guidance tools for interventional …

Aims To investigate local haemodynamics in the setting of acute coronary plaque rupture
and erosion. Methods and results Intracoronary optical coherence tomography performed in …

Despite all the advances of modern medicine, atherosclerosis continues to be one of the
most important medical and social problems. Atherosclerosis is the cause of several …

Background The combination of medical imaging and computational hemodynamics is a
promising technology to diagnose/prognose coronary artery disease (CAD). However, the …

Background and aims Wall shear stress (WSS) has been associated with atherogenesis and
plaque progression. The present study assessed the value of WSS analysis derived from …

Hemodynamics interacts with the cellular components of human vessels, influencing
function and healthy status. Locally acting hemodynamic forces have been associated—by a …

Background This work aims to present a fast, affordable, and reproducible three-cell co-
culture system that could represent the different cellular mechanisms of atherosclerosis …

High-risk coronary plaque refers to a distinct set of plaque characteristics prone to future
coronary events. Coronary physiology represents a group of indexes reflective of the local …

Endothelial nitric oxide synthase (eNOS) decreases following inflammatory stimulation. As a
master regulator of endothelial homeostasis, maintaining optimal eNOS levels is important …