Non-small-cell lung cancers (NSCLCs), the most common lung cancers, are known to have
diverse pathological features. During the past decade, in-depth analyses of lung cancer …

Non-small-cell lung cancer (NSCLC) constitutes 85% of all lung cancers, and is the leading
cause of cancer-related death worldwide. The poor prognosis and resistance to both …

Introduction: Adenocarcinoma is the most common histologic type of lung cancer. To
address advances in oncology, molecular biology, pathology, radiology, and surgery of lung …

Purpose A number of studies have investigated the relationship between microsatellite
instability (MSI) and colorectal cancer (CRC) prognosis. Although many have reported a …

Molecular heterogeneity is a frequent event in cancer responsible of several critical issues in
diagnosis and treatment of oncologic patients. Lung tumours are characterized by high …

Lung cancer continues to be a malignant tumor with high mortality. Two obstacles interfere
with curative therapy of lung cancer:(i) poor diagnosis at the early stages, as symptoms are …

The tumor suppressor gene TP53 is frequently mutated in human cancers. Abnormality of
the TP53 gene is one of the most significant events in lung cancers and plays an important …

This issue marks the 50th anniversary of the release of the US Surgeon General's Report on
Smoking and Health. Perhaps no other singular event has done more to highlight the effects …

Objectives Non-small cell lung cancer (NSCLC) is a heterogeneous disease with unique
combinations of somatic molecular alterations in individual patients, as well as significant …

We report a direct comparison of the differential effects of individual p53 mutations on lung
tumor growth and progression, and the creation of a murine model of spontaneous …