Chromatin structure and gene expression are dynamically controlled by post-translational
modifications (PTMs) on histone proteins, including ubiquitylation, methylation, acetylation …

Genetic and genomic techniques have proven incredibly powerful for identifying and
studying molecular players implicated in the epigenetic regulation of DNA-templated …

Cells reprogram their transcriptomes to adapt to external conditions. The SAGA (Spt-Ada-
Gcn5 acetyltransferase) complex is a highly conserved transcriptional coactivator that plays …

Transcription-replication conflicts (TRCs) occur when intensive transcriptional activity
compromises replication fork stability, potentially leading to gene mutations. Transcription …

In mammalian cells, the SET1/MLL complexes are the main writers of the H3K4 methyl mark
that is associated with active gene expression. The activities of these complexes are …

Histone lysine methylation is a key epigenetic modification that regulates eukaryotic
transcription. Here, we comprehensively review the function and regulation of the histone …

DNA replication initiates at genomic locations known as origins of replication, which, in S.
cerevisiae, share a common DNA consensus motif. Despite being virtually nucleosome-free …

Abstract Histone 3 lysine 4 trimethylation (H3K4me3) is an epigenetic mark found at gene
promoters and CpG islands. H3K4me3 is essential for mammalian development, yet …

Methylation of histone 3 lysine 4 (H3K4) is a major epigenetic system associated with gene
expression. In mammals there are six H3K4 methyltransferases related to yeast Set1 and fly …

In mammals, histone 3 lysine 4 methylation (H3K4me) is mediated by six different lysine
methyltransferases. Among these enzymes, SETD1B (SET domain containing 1b) has been …