Discovery of plant-derived anti-tumor natural products: Potential leads for anti-tumor drug discovery

Z Hui, H Wen, J Zhu, H Deng, X Jiang, XY Ye… - Bioorganic …, 2023 - Elsevier
Natural products represent a paramount source of novel drugs. Numerous plant-derived
natural products have demonstrated potent anti-tumor properties, thereby garnering …

Complex roles for sulfation in the toxicities of polychlorinated biphenyls

MW Duffel, HJ Lehmler - Critical reviews in toxicology, 2024 - Taylor & Francis
Polychlorinated biphenyls (PCBs) are persistent organic toxicants derived from legacy
pollution sources and their formation as inadvertent byproducts of some current …

Lipid Peroxidation in Muscle Foods: Impact on Quality, Safety and Human Health

SG Dragoev - Foods, 2024 - mdpi.com
The issue of lipid changes in muscle foods under the action of atmospheric oxygen has
captured the attention of researchers for over a century. Lipid oxidative processes initiate …

Insight into the Antioxidant Activity of 1, 8-Dihydroxynaphthalene Allomelanin Nanoparticles

A Mavridi-Printezi, F Mollica, R Lucernati, M Montalti… - Antioxidants, 2023 - mdpi.com
Melanins are stable and non-toxic pigments with great potential as chemopreventive agents
against oxidative stress for medical and cosmetic applications. Allomelanin is a class of …

On the role of ROS and glutathione in the mode of action underlying Nrf2 activation by the hydroxyanthraquinone purpurin

Q Ren, W Bakker, S Wesseling, H Bouwmeester… - Antioxidants, 2023 - mdpi.com
Purpurin is a major anthraquinone present in the roots of Rubia cordifolia (madder).
Purpurin is known to activate Nrf2 (Nuclear transcription factor erythroid 2-related factor 2) …

[HTML][HTML] Co-exposure of microcystin and nitrite enhanced spermatogenic disorders: The role of mtROS-mediated pyroptosis and apoptosis

H Liu, X Du, Z Zhang, K Ge, X Chen… - Environment …, 2024 - Elsevier
Microcystins (MCs) and nitrites are coexisted in the environment and have reproductive
toxicity. The combined toxic effect and mechanism of MCs and nitrite on spermatogenesis …

New synergistic benzoquinone scaffolds as inhibitors of mycobacterial cytochrome bc1 complex to treat multi-drug resistant tuberculosis

NB Chilamakuru, AD Vn, N Pallaprolu, A Dande… - European Journal of …, 2024 - Elsevier
Through a comprehensive molecular docking study, a unique series of naphthoquinones
clubbed azetidinone scaffolds was arrived with promising binding affinity to Mycobacterial …

[HTML][HTML] LOCATION AND INTERACTION OF IDEBENONE AND MITOQUINONE IN A MEMBRANE SIMILAR TO THE INNER MITOCHONDRIAL MEMBRANE …

J Villalaín - Free Radical Biology and Medicine, 2024 - Elsevier
Oxygen is essential for aerobic life on earth but it is also the origin of harmful reactive
oxygen species (ROS). Ubiquinone is par excellence the endogenous cellular antioxidant …

Role of Mitochondrial Reactive Oxygen Species in Chemically-Induced Ferroptosis1

X Song, X Hao, BT Zhu - Free Radical Biology and Medicine, 2024 - Elsevier
Ferroptosis is a form of iron-dependent regulated cell death which is different from
apoptosis. Chemically-induced ferroptosis is characterized by an accumulation of lipid …

Exploring the Pharmacological Potential of Lithospermum officinale L.: A Review of Phytochemicals and Ethnomedicinal Uses

G Barkizatova, A Turgumbayeva, K Zhakipbekov… - Molecules, 2024 - mdpi.com
Exploring phytochemicals from ethnomedicinal plants for pharmacological applications is a
promising research area. By studying ethnomedicine, researchers can identify plants used …