Recent evidence clearly shows that cells respond to various physical cues in their
environments, guiding many cellular processes and tissue morphogenesis, pathology, and …

The nuclear lamina is an important structural determinant for the nuclear envelope as a
whole, attaching chromatin domains to the nuclear periphery and localizing some nuclear …

Introduction Tissues can be soft like brain, bone marrow, and fat, which bear little
mechanical stress, or stiff like muscle, cartilage, and bone, which sustain high levels of …

Tissue mechanics drive morphogenesis, but how forces are sensed and transmitted to
control stem cell fate and self-organization remains unclear. We show that a …

We have developed a new technique for proximity-dependent labeling of proteins in
eukaryotic cells. Named BioID for proximity-dependent biotin identification, this approach is …

Many forms of cancer have multiple subtypes with different causes and clinical outcomes.
Somatic tumor genome sequences provide a rich new source of data for uncovering these …

Cells are constantly subjected to a spectrum of mechanical cues, such as shear stress,
compression, differential tissue rigidity and strain, to which they adapt by engaging …

We recently discovered signal-regulated nuclear actin network assembly. However, in
contrast to cytoplasmic actin regulation, polymeric nuclear actin structures and functions …

Since the discovery nearly 60 years ago, cAMP is envisioned as one of the most universal
and versatile second messengers. The tremendous feature of cAMP to tightly control highly …

How cells respond to physical cues in order to meet and withstand the physical demands of
their immediate surroundings has been of great interest for many years, with current …