Despite two decades of intensified research to understand and cure tuberculosis disease,
biological uncertainties remain and hamper progress. However, owing to collaborative …

Tuberculosis (TB) is a major cause of morbidity and mortality worldwide. It is estimated that
25% of the world's population are infected with Mycobacterium tuberculosis, with a 5–10 …

Coronavirus disease has disrupted tuberculosis services globally. Data from 33 centers in
16 countries on 5 continents showed that attendance at tuberculosis centers was lower …

Latent tuberculosis infection was the term traditionally used to indicate tuberculosis (TB)
infection. This term was used to define “a state of persistent immune response to stimulation …

ABSTRACT Objectives The World Health Organization estimated that a quarter of the global
population is infected by Mycobacterium tuberculosis (Mtb). A better control of tuberculosis …

Circular RNA (circRNA) is a novel class of single-stranded RNAs with a closed loop
structure. The majority of circRNAs are formed by a back-splicing process in pre-mRNA …

BACKGROUND: Tuberculosis (TB) preventive therapy (TPT) decreases the risk of
developing TB disease and its associated morbidity and mortality. The aim of these clinical …

Blood transcriptomics have revealed major characteristics of the immune response in active
TB, but the signature early after infection is unknown. In a unique clinically and temporally …

We currently have a binomial approach to managing tuberculosis. Those with active
disease, ideally confirmed microbiologically, are treated with a standard 6-month, multi-drug …

Background Only the tuberculin skin test (TST) and two interferon-γ release assays (IGRAs),
QuantiFERON-TB Gold In-Tube and T-SPOT. TB, are currently endorsed by the World …