Simple Summary Nephrotoxicity is the dose-limiting factor of cisplatin treatment.
Nephrotoxicity is characterized by reduced kidney function. Although an often-reversible …

Calreticulin (CRT), when localized to the endoplasmic reticulum (ER), has important
functions in directing proper conformation of proteins and glycoproteins, as well as in …

The endoplasmic reticulum (ER) is the cellular organelle responsible for protein folding and
assembly, lipid and sterol biosynthesis, and calcium storage. The unfolded protein response …

The endoplasmic reticulum (ER) is a multifunctional organelle that constitutes the entry into
the secretory pathway. The ER contributes to the maintenance of cellular calcium …

Recent studies have suggested a link between inhaled particulate matter (PM) exposure
and increased mortality and morbidity associated with pulmonary and cardiovascular …

There has been much effort to define the molecular basis by which pathophysiological
stimuli initiate and/or propagate the inflammatory response. Recent research endeavors on …

The unfolded protein response (UPR) is a cascade of intracellular stress signaling events in
response to an accumulation of unfolded or misfolded proteins in the lumen of the …

Endoplasmic reticulum (ER) stress has been implicated in alveolar epithelial type II (AT2)
cell apoptosis in idiopathic pulmonary fibrosis. We hypothesized that ER stress (either …

The endoplasmic reticulum (ER) is a critical organelle that synthesizes secretory proteins
and serves as the main calcium storage site of the cell. The accumulation of unfolded …

The endoplasmic reticulum (ER) is the primary intracellular organelle responsible for protein
and lipid biosynthesis, protein folding and trafficking, calcium homeostasis, and several …