Recently, there has been an increasing interest in the development and characterization of
patient-derived tumor xenograft (PDX) models for cancer research. PDX models mostly …

Although pancreatic cancer (PC) was considered in the past an orphan cancer type due to
its low incidence, it may become in the future one of the leading causes of cancer death …

Pancreatic cancer is expected to be the second deadliest malignancy in the USA by 2020.
The survival rates for patients with other gastrointestinal malignancies have increased …

Establishing an appropriate preclinical model is crucial for translational cancer research.
The most common way that has been adopted by far is grafting cancer cell lines, derived …

Background While patient-derived xenografts (PDXs) offer a powerful modality for
translational cancer research, a precise evaluation of how accurately patient responses …

Progress in oncology drug development has been hampered by a lack of preclinical models
that reliably predict clinical activity of novel compounds in cancer patients. In an effort to …

Rationale: Hepatocellular carcinoma (HCC) is an aggressive malignant solid tumor wherein
CDK1/PDK1/β-Catenin is activated, suggesting that inhibition of this pathway may have …

Over the last few decades, study of cancer in mouse models has gained popularity.
Sophisticated genetic manipulation technologies and commercialization of these murine …

Pancreatic cancer is the fourth leading cause of cancer death in the US and is expected to
become the second leading cause of cancer-related deaths in the next decade. Despite 5 …

Pancreatic ductal adenocarcinomas contain a subset of exclusively tumorigenic cancer stem
cells (CSCs), which are capable of repopulating the entire heterogeneous cancer cell …