[HTML][HTML] 15 years of GWAS discovery: realizing the promise
It has been 15 years since the advent of the genome-wide association study (GWAS) era.
Here, we review how this experimental design has realized its promise by facilitating an …
Here, we review how this experimental design has realized its promise by facilitating an …
Discovery and implications of polygenicity of common diseases
The sequencing of the human genome has allowed the study of the genetic architecture of
common diseases: the number of genomic variants that contribute to risk of disease and …
common diseases: the number of genomic variants that contribute to risk of disease and …
LDpred2: better, faster, stronger
Motivation Polygenic scores have become a central tool in human genetics research.
LDpred is a popular method for deriving polygenic scores based on summary statistics and …
LDpred is a popular method for deriving polygenic scores based on summary statistics and …
[HTML][HTML] Mechanisms of neuroplasticity linking early adversity to depression: developmental considerations
Early exposure to psychosocial adversity is among the most potent predictors of depression.
Because depression commonly emerges prior to adulthood, we must consider the …
Because depression commonly emerges prior to adulthood, we must consider the …
Challenging the utility of polygenic scores for social science: Environmental confounding, downward causation, and unknown biology
CH Burt - Behavioral and brain sciences, 2023 - cambridge.org
The sociogenomics revolution is upon us, we are told. Whether revolutionary or not,
sociogenomics is poised to flourish given the ease of incorporating polygenic scores (or …
sociogenomics is poised to flourish given the ease of incorporating polygenic scores (or …
Cultural evolution of genetic heritability
R Uchiyama, R Spicer… - Behavioral and Brain …, 2022 - cambridge.org
Behavioral genetics and cultural evolution have both revolutionized our understanding of
human behavior–largely independent of each other. Here, we reconcile these two fields …
human behavior–largely independent of each other. Here, we reconcile these two fields …
[HTML][HTML] The body keeps the score: The neurobiological profile of traumatized adolescents
D Laricchiuta, A Panuccio, E Picerni, D Biondo… - … & biobehavioral reviews, 2023 - Elsevier
Trauma-related disorders are debilitating psychiatric conditions that affect people who have
directly or indirectly witnessed adversities. Experiencing multiple types of traumas appears …
directly or indirectly witnessed adversities. Experiencing multiple types of traumas appears …
Toward a better understanding of the causal effects of role demands on work–family conflict: A genetic modeling approach.
Over the past several decades, there has been considerable interest in the theoretical
causes of work–family conflict (WFC). Most studies have focused on situational …
causes of work–family conflict (WFC). Most studies have focused on situational …
[PDF][PDF] Interactions between poly genic scores and envi ron ments: Methodological and con cep tual chal lenges
BW Domingue, S Trejo… - Sociologi-cal …, 2020 - sociologicalscience.com
Interest in the study of gene–environment interaction has recently grown due to the sudden
availability of molecular genetic data—in particular, polygenic scores—in many long-running …
availability of molecular genetic data—in particular, polygenic scores—in many long-running …
Evaluating the continued integration of genetics into medical sociology
JD Boardman, JM Fletcher - Journal of Health and Social …, 2021 - journals.sagepub.com
The 2010 special issue of Journal of Health and Social Behavior, titled “Fifty Years of
Medical Sociology,” defined the contours of the medical sociological perspective. We use …
Medical Sociology,” defined the contours of the medical sociological perspective. We use …