Functional roles of JNK and p38 MAPK signaling in nasopharyngeal carcinoma
c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinase (MAPK) family
members integrate signals that affect proliferation, differentiation, survival, and migration in a …
members integrate signals that affect proliferation, differentiation, survival, and migration in a …
Role of p38 MAP kinase signal transduction in solid tumors
HK Koul, M Pal, S Koul - Genes & cancer, 2013 - journals.sagepub.com
Mitogen-activated protein kinases (MAPKs) mediate a wide variety of cellular behaviors in
response to extracellular stimuli. One of the main subgroups, the p38 MAP kinases, has …
response to extracellular stimuli. One of the main subgroups, the p38 MAP kinases, has …
The p38 signal transduction pathway activation and function
The p38 signalling transduction pathway, a Mitogen-activated protein (MAP) kinase
pathway, plays an essential role in regulating many cellular processes including …
pathway, plays an essential role in regulating many cellular processes including …
Signal transduction mechanisms mediating the physiological and pathophysiological actions of angiotensin II in vascular smooth muscle cells
RM Touyz, EL Schiffrin - Pharmacological reviews, 2000 - ASPET
Until recently, the signaling events elicited in vascular smooth muscle cells by angiotensin II
(Ang II) were considered to be rapid, short-lived, and divided into separate linear pathways …
(Ang II) were considered to be rapid, short-lived, and divided into separate linear pathways …
Mechanisms of tamoxifen resistance
A Ring, M Dowsett - Endocrine-related cancer, 2004 - erc.bioscientifica.com
The anti-oestrogen tamoxifen is the most commonly used treatment for patients with
oestrogen-receptor (ER)-positive breast cancer. Although many patients benefit from …
oestrogen-receptor (ER)-positive breast cancer. Although many patients benefit from …
The proinflammatory cytokines interleukin-1beta and tumor necrosis factor-alpha activate serotonin transporters
CB Zhu, RD Blakely, WA Hewlett - Neuropsychopharmacology, 2006 - nature.com
Proinflammatory cytokines and serotonergic homeostasis have both been implicated in the
pathophysiology of major psychiatric disorders. We have demonstrated that activation of p38 …
pathophysiology of major psychiatric disorders. We have demonstrated that activation of p38 …
Mitogen-activated protein kinases: new signaling pathways functioning in cellular responses to environmental stress
The mitogen-activated protein kinase (MAPK) superfamily consists of three main protein
kinase families: the extracellular signal-regulated protein kinases (ERKs), the c-Jun N …
kinase families: the extracellular signal-regulated protein kinases (ERKs), the c-Jun N …
Mechanisms of resistance to endocrine therapy in breast cancer: focus on signaling pathways, miRNAs and genetically based resistance
R García-Becerra, N Santos, L Díaz… - International journal of …, 2012 - mdpi.com
Breast cancer is the most frequent malignancy diagnosed in women. Approximately 70% of
breast tumors express the estrogen receptor (ER). Tamoxifen and aromatase inhibitors (AIs) …
breast tumors express the estrogen receptor (ER). Tamoxifen and aromatase inhibitors (AIs) …
Mechanical stress-induced cardiac hypertrophy: mechanisms and signal transduction pathways
C Ruwhof, A van der Laarse - Cardiovascular research, 2000 - academic.oup.com
Cardiac hypertrophy is a well known response to increased hemodynamic load. Mechanical
stress is considered to be the trigger inducing a growth response in the overloaded …
stress is considered to be the trigger inducing a growth response in the overloaded …
The role of p38 MAPK and its substrates in neuronal plasticity and neurodegenerative disease
SAL Corrêa, KL Eales - Journal of signal transduction, 2012 - Wiley Online Library
A significant amount of evidence suggests that the p38‐mitogen‐activated protein kinase
(MAPK) signalling cascade plays a crucial role in synaptic plasticity and in …
(MAPK) signalling cascade plays a crucial role in synaptic plasticity and in …