c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinase (MAPK) family
members integrate signals that affect proliferation, differentiation, survival, and migration in a …

Mitogen-activated protein kinases (MAPKs) mediate a wide variety of cellular behaviors in
response to extracellular stimuli. One of the main subgroups, the p38 MAP kinases, has …

The p38 signalling transduction pathway, a Mitogen-activated protein (MAP) kinase
pathway, plays an essential role in regulating many cellular processes including …

Until recently, the signaling events elicited in vascular smooth muscle cells by angiotensin II
(Ang II) were considered to be rapid, short-lived, and divided into separate linear pathways …

The anti-oestrogen tamoxifen is the most commonly used treatment for patients with
oestrogen-receptor (ER)-positive breast cancer. Although many patients benefit from …

Proinflammatory cytokines and serotonergic homeostasis have both been implicated in the
pathophysiology of major psychiatric disorders. We have demonstrated that activation of p38 …

The mitogen-activated protein kinase (MAPK) superfamily consists of three main protein
kinase families: the extracellular signal-regulated protein kinases (ERKs), the c-Jun N …

Breast cancer is the most frequent malignancy diagnosed in women. Approximately 70% of
breast tumors express the estrogen receptor (ER). Tamoxifen and aromatase inhibitors (AIs) …

Cardiac hypertrophy is a well known response to increased hemodynamic load. Mechanical
stress is considered to be the trigger inducing a growth response in the overloaded …

A significant amount of evidence suggests that the p38‐mitogen‐activated protein kinase
(MAPK) signalling cascade plays a crucial role in synaptic plasticity and in …