Brain‐Targeted Black Phosphorus‐Based Nanotherapeutic Platform for Enhanced Hypericin Delivery in Depression

H Tan, K Cao, Y Zhao, J Zhong, D Deng, B Pan… - Small, 2024 - Wiley Online Library
Depression is a significant global health concern that remains inadequately treated due to
the limited effectiveness of conventional drug therapies. One potential therapeutic agent …

[HTML][HTML] Mitochondrial dynamics dysfunction: Unraveling the hidden link to depression

H Chen, M Lu, Q Lyu, L Shi, C Zhou, M Li… - Biomedicine & …, 2024 - Elsevier
Depression is a common mental disorder and its pathogenesis is not fully understood.
However, more and more evidence shows that mitochondrial dynamics dysfunction may …

Ferroptosis: a new antidepressant pharmacological mechanism

G Zhang, S Lv, X Zhong, X Li, Y Yi, Y Lu… - Frontiers in …, 2024 - frontiersin.org
The incidence rate of depression, a mental disorder, is steadily increasing and has the
potential to become a major global disability factor. Given the complex pathological …

Low-dose BPA-induced neuronal energy metabolism dysfunction and apoptosis mediated by PINK1/parkin mitophagy pathway in juvenile rats

L Meng, Z Ouyang, Y Chen, C Huang, Y Yu… - Science of The Total …, 2024 - Elsevier
Bisphenol A (BPA) is related to neurological disorders involving mitochondrial dysfunction,
while the mechanism remains elusive. Therefore, we explored it through in vitro and in vivo …

A comprehensive analysis of the differential expression in the hippocampus of depression induced by gut microbiota compared to traditional stress

X Chen, X Mo, Y Zhang, D He, R Xiao, Q Cheng… - Gene, 2024 - Elsevier
Depression, which is a disease of heterogeneous etiology, is characterized by high disability
and mortality rates. Gut microbiota are associated with the development of depression. To …

Pharmacological mechanism of natural antidepressants: the role of mitochondrial quality control

S Lv, G Zhang, Y Lu, X Zhong, Y Huang, Y Ma, W Yan… - Phytomedicine, 2024 - Elsevier
Background Depression is a mental illness characterized by persistent sadness and a
reduced capacity for pleasure. In clinical practice, SSRIs and other medications are …

L-Carnitine in the Treatment of Psychiatric and Neurological Manifestations: A Systematic Review

W Wang, D Pan, Q Liu, X Chen, S Wang - Nutrients, 2024 - mdpi.com
Objective: L-carnitine (LC), a vital nutritional supplement, plays a crucial role in myocardial
health and exhibits significant cardioprotective effects. LC, being the principal constituent of …

Advancements in the study of synaptic plasticity and mitochondrial autophagy relationship

Y Zhu, Q Hui, Z Zhang, H Fu, Y Qin… - Journal of …, 2024 - Wiley Online Library
Synapses serve as the points of communication between neurons, consisting primarily of
three components: the presynaptic membrane, synaptic cleft, and postsynaptic membrane …