Resolving the unsolved: comprehensive assessment of tandem repeats at scale
Tandem repeat (TR) variation is associated with gene expression changes and over 50 rare
monogenic diseases. Recent advances in sequencing have enabled accurate, long reads …
monogenic diseases. Recent advances in sequencing have enabled accurate, long reads …
[HTML][HTML] CRISPR–Cas9-targeted fragmentation and selective sequencing enable massively parallel microsatellite analysis
Microsatellites are multi-allelic and composed of short tandem repeats (STRs) with
individual motifs composed of mononucleotides, dinucleotides or higher including …
individual motifs composed of mononucleotides, dinucleotides or higher including …
100 years of evolving gene–disease complexities and scientific debutants
It's been over 100 years since the wordgene'is around and progressively evolving in several
scientific directions. Time-to-time technological advancements have heavily revolutionized …
scientific directions. Time-to-time technological advancements have heavily revolutionized …
Revisiting tandem repeats in psychiatric disorders from perspectives of genetics, physiology, and brain evolution
Genome-wide association studies (GWASs) have revealed substantial genetic components
comprised of single nucleotide polymorphisms (SNPs) in the heritable risk of psychiatric …
comprised of single nucleotide polymorphisms (SNPs) in the heritable risk of psychiatric …
Tandem repeat variation in human and great ape populations and its impact on gene expression divergence
TB Sonay, T Carvalho, MD Robinson… - Genome …, 2015 - genome.cshlp.org
Tandem repeats (TRs) are stretches of DNA that are highly variable in length and mutate
rapidly. They are thus an important source of genetic variation. This variation is highly …
rapidly. They are thus an important source of genetic variation. This variation is highly …
Mutation protocols share with sexual reproduction the physiological role of producing genetic variation within 'constraints that deconstrain'
DG King - The Journal of Physiology, 2024 - Wiley Online Library
Because the universe of possible DNA sequences is inconceivably vast, organisms have
evolved mechanisms for exploring DNA sequence space while substantially reducing the …
evolved mechanisms for exploring DNA sequence space while substantially reducing the …
Identification, comparative and phylogenetic analysis of eight Vitis species based on the chloroplast genome revealed their contribution to heat tolerance in …
L Zhang, Y Song, J Li, J Liu, Z Zhang, Y Xu, D Fan… - Scientia …, 2024 - Elsevier
The chloroplast genome plays an important role in exploring the origin and evolution of
grapes. In this study, the chloroplast genomes of eight grape germplasms were analyzed …
grapes. In this study, the chloroplast genomes of eight grape germplasms were analyzed …
A hypermutable region in the DISP2 gene links to natural selection and late-onset neurocognitive disorders in humans
S Khamse, S Alizadeh, HRK Khorshid, A Delbari… - Molecular …, 2024 - Springer
Abstract (CCG) short tandem repeats (STRs) are predominantly enriched in genic regions,
mutation hotspots for C to T truncating substitutions, and involved in various neurological …
mutation hotspots for C to T truncating substitutions, and involved in various neurological …
Massive variation of short tandem repeats with functional consequences across strains of Arabidopsis thaliana
Short tandem repeat (STR) mutations may comprise more than half of the mutations in
eukaryotic coding DNA, yet STR variation is rarely examined as a contributor to complex …
eukaryotic coding DNA, yet STR variation is rarely examined as a contributor to complex …
The emerging role of tandem repeats in complex traits
M Lamkin, M Gymrek - Nature Reviews Genetics, 2024 - nature.com
Tandem repeats are a large source of genetic variation but are challenging to analyse and
have been missing from most genome-wide studies. Results now suggest that systematic …
have been missing from most genome-wide studies. Results now suggest that systematic …