A significant clinical issue encountered after a successful acute major depressive disorder
(MDD) treatment is the relapse of depressive symptoms. Although continuing maintenance …

Weight gain during antidepressant treatment can be either a sign of improvement in patients
who have weight loss as a symptom of depression or a residual symptom in patients who …

A revision of the 2008 British Association for Psychopharmacology evidence-based
guidelines for treating depressive disorders with antidepressants was undertaken in order to …

A revision of the 2000 British Association for Psychopharmacology evidence-based
guidelines for treating depressive disorders with antidepressants was undertaken to …

Background Antidepressants are among the most commonly prescribed drugs worldwide.
They are often discontinued, frequently without the knowledge of the prescribing physician. It …

In recent years there has been a considerable debate on antidepressant drugs. Continued
drug treatment with antidepressant medications may stimulate processes that run counter to …

Duloxetine is a serotonin-norepinephrine reuptake inhibitor approved for the treatment of
patients affected by major depressive disorder (MDD), generalized anxiety disorder (GAD) …

There is increasing awareness that, in some cases, long-term use of antidepressant drugs
(AD) may enhance the biochemical vulnerability to depression and worsen its long-term …

Background: Antidepressants are effective in the prevention of relapse after remission from
an acute depressive episode. It is unclear, however, to what degree duration of the …

The prevalence of a return of depressive symptoms during maintenance AD treatment was 9–
57% in published trials [6], pointing to an occurrence of tolerance phenomena during AD …