Gene targeting is the use of homologous recombination to make defined alterations to the
genome. One of the possible outcomes of gene targeting is the accurate correction of …

Methods are now widely used in mice, and to a lesser extent in mammalian-cell culture, for
the constitutive silencing of target genes in order to assess their function. For a variety of …

The present invention provides tissues derived from animals, which lack any expression of
functional alpha 1, 3 galactosyltransferase (alpha-1, 3-GT). Such tissues can be used in the …

The present invention is a porcine animal, tissue, organ, cells and cell lines, which lack any
expression of functional alpha 1, 3 galactosyltransferase (alpha1, 3GT). These animals …

Oligonucleotide-and polynucleotide-based gene modification strategies were developed as
an alternative to transgene-based and classical gene targeting-based gene therapy …

Despite enormous effort, progress in reducing mortality from cancer remains modest. Can a
true cancer “cure” ever be developed, given the vast versatility that tumors derive from their …

Related US Application Data Continuation of application No. 14/449,969, filed on Aug. 1,
2014, now Pat. No. 10,130,737, which is a continuation of application No. 13/334,194, filed …

The present invention provides tissues derived from animals, which lack any expression of
functional alpha 1, 3 galactosyltransferase (alpha-1, 3-GT). Such tissues can be used in the …

Background. Our purpose was to develop and evaluate protocols for selective
immunosuppression after liver transplantation using the monoclonal antibodies (mAbs) NDS …

EP O669829 B1 8, 2001 WO WO 94, 02616 A1 2, 1994 WO WO94, 098O3 A1 5, 1994
sequence. The present also invention includes porcine ani mals, tissue and organs as well …